Microbial DNA and Host Immunity
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Microbial DNA and Host Immunity

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Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).show more

Product details

  • Hardback | 408 pages
  • 159 x 244.3 x 29mm | 816.48g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2002 ed.
  • 95 black & white illustrations, biography
  • 1588290220
  • 9781588290229

Back cover copy

The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis). Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease.show more

Review quote

"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News "This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journalshow more

Table of contents

Part I. Introduction Immunostimulatory DNA: An Overview Eyal Raz Historical Perspectives Saburo Yamamoto, Toshiko Yamamoto, and Tohru Tokunaga Part II. Receptors and Signaling Signal Transduction Pathways Activated by CpG-DNA Hans Hacker A Novel Toll-Like Receptor that Recognizes Bacterial DNA Hiroaki Hemmi and Shizuo Akira Activation of Innate Immunity by Microbial Nucleic Acids Wen-Ming Chu, Xing Gong, and Tony Yoon Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. Hume Part III. Cell Activation Activation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and Human Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, and Tohru Tokunaga Regulation of Antigen Presenting Cell Function by CpG-DNA David Askew, Rose S. Chu, and Clifford V. Harding Activation of B Cells by CpG Motifs in Bacterial DNA, Ae-Kyung Yi and Arthur M. Krieg IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells Jonathan Sprent Cross Priming of CD8+ T Cells by Immunostimulatory Sequence DNA Hearn Jay Cho, Sandip Datta, and Eyal Raz Part IV. Vaccination Strategies The Th1 Adjuvant Effect of Immunostimulatory DNA Sequences Maripat Corr and Chih Min Tang Immunostimulatory DNA Pre-Priming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, and Anthony A. Horner Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen Kenji Takabayashi, Helen Tighe, Lucinda Beck, and Hans L. Spiegelberg Immunostimulatory DNA Sequence-Based Mucosal Vaccines Anthony A. Horner Enhancement of the Immunoadjuvant Activity ofImmunostimulatory DNA Sequence by Liposomal Delivery Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, and Yechezkel Barenholz. Immunostimulatory Sequences in Plasmid Vectors Christina C. N. Wu, Chih Min Tang, Brian Crain, and Maripat Corr Part V. Applications-Infectious Disease Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B Michael J. McCluskie, Risini D. Weeratna, and Heather L. Davis Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine? Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, and Eyal Raz Immunoprotective Activity of CpG Oligonucleotides Dennis M. Klinman, Ken J. Ishii, and Ihsan Gursel Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, and Antonino Cantanzaro Part VI. Applications-Allergy DNA-Based Immunotherapeutics for Allergic Disease Anthony A. Horner and Eyal Raz Immunostimulatory DNA for Allergic Asthma Reid K. Ikeda, Kenji Takabayashi, and David Broide CpG Oligodeoxynucleotides in Asthma Kunihiko Kitagaki and Joel N. Kline Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides Andrea Keane-Myers and Chi-Chao Chan Part VII. Applications-Cancer CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma Thomas L. Warren and George J. Weiner Part VIII. Inflammation and Autoimmunity The Antigenicity of Bacterial DNA David S. Pisetsky Inflammatogenic Properties of Immunostimulatory DNA Sequences Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, and Leno Molne The Role of Immunostimulatory DNA Sequences in Arthritis Sarah T.A. Roord, Arash Ronaghy, Berent J.show more