Methods in Neurosciences: Neurobiology of Cytokines v.16

Methods in Neurosciences: Neurobiology of Cytokines v.16

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Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume, and its companion Volume 17, is to provide an overview of the effects of cytokines in the brain and on the endocrine system. Topics covered include: general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the bloodbrain barrier; the anatomical localization of cytokines, cytokine receptors and their respective mRNA in brain and in endocrine tissues; methods for evaluating the "in vivo" and "in vitro" actions of cytokines on hormone secretion.
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Product details

  • Hardback | 317 pages
  • 203.2 x 230 x 19.05mm | 840g
  • Academic Press Inc
  • San Diego, United States
  • English
  • index
  • 0121852814
  • 9780121852818

Table of contents

General Aspects: S.K. Dower, Pharmacological, Biochemical, and Molecular Biological Studies on Cytokine Receptors. D.B. Carter, A.E. Berger, and D.E. Tracey, Genetic Regulation and Activities of an Interleukin-1 Receptor Antagonist Protein. G.A. Evans, H. Rui, and W.L. Farrar, Identification of Intracellular Mediators of the Actions of Cytokines: Identifying Proteins Involved in Kinase Signalling Pathways. W.A. Banks and A.J Kastin, Measurement of Transport of Cytokines Across the Blood-Brain Barrier. Anatomical Localization Studies: M.-L. Wong, P. W. Gold, and J. Licinio, In Situ Hybridization Techniques for Localization of Interleukin- 1 and lnterleukin- 1 Receptor Antagonist MRNA in Brain. J.A. Olschowka, Immunocytochemical Methods for Localization of Cytokines in Brain. E.T. Cunningham, Jr. and E B. DeSouza, Localization of Type I Interleukin- I Receptor MRNA in Brain and Endocrine Tissues Using In Situ Hybridization Histochemistry. T. Takao, D.E. Grigoriadis, and E.B. DeSouza, Identification, Autoradiographic Localization, and Modulation of Interleukin- 1 Receptors in Brain-Endocrine- Immune Axis: Methodology and Overview. A. Ericsson and P.E. Sawchenko, c-fos-Based Functional Mapping of Central Pathways Subserving Effects of Interleukin- 1 on Hypothalamo-Pituitary-Adrenal Axis. D. Seto, U. Hanisch, F Villemain, A. Beaudet and R. Quirion, Anatomical and Functional Approaches to Study of Interieukin-2 and its Receptors in Brain. Neuro endocrine Actions: S.M. McCann, L. Milenkovic, M.C. Gonzalez, K. Lyson, S. Karanth, and V. Rettori, Endocrine Aspects of Neuroimmunomodulation: Methods and Overview. F Berkenbosch, N. Van Rooijen, and F.J.H. Tilders, Determining Role and Sources of Endogenous Interleukin- 1 in Pituitary-Adrenal Activation to Stressful and Inflamatory Stimuli. J Fukata, H. Segawa, Y. Naito, N. Murakami, H. Kobayashi, O. Ebisui, T. Usui, and H. Imura, In Vivo and In Vitro Methods for Studying Effects of Cytokines on Adrenocorticotropic Hormone, Arginine Vasopressin, and Oxytocin Secretion. P. S. Kaira and S.P. Kalra, In Vivo and In Vitro Models for Evaluating Effects of Interleukin- 1 on Hypothalamic-Pituitary-Gonadal Axis. A. Arimura and P.E Gottschall, Methodological Evaluation of Sites and Mechanisms of Action Involved in Neuroendocrine Effects of Cytokines. A.E. Panerai, V. Locatelli, and P. Sacerdote, In Vivo and In Vitro Methods for Studying Effects of Tumour Necrosis Factor on Pituitary Cells. A. Grossman, S. Tsagarakis, M. Korbonits, and A. Costa, Determination of Direct Effects of Cytokines on Release of Neuropeptides from Rat Hypothalamus by an In Vitro Method. M.0. Fagarasan, Effects of Interleukin- 1 on b-Endorphin Secretion in Att-20 Pituitary Cells: Methods and Overview.
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