Part 1 Examples of problems - vignettes: setting up the analysis - formulating the problem; organizing the evidence; types of evidence; biases; summarizing the evidence; influence diagrams; models for combining evidence; introduction to Bayes' Formula. Part 2 Formulas of the confidence profile method: components of the confidence profile method; the general model; prior distributions; likelihood functions; bias functions; other functions; solution methods. Part 3 Solutions to the example problems: analysis of tamoxifen; analysis of HIP trial of breast cancer screening; analysis of Ulrecht Project (DOM); analysis of breast cancer screening - seven controlled trials; Analysis of Breast Cancer Detection Demonstration Project (BCDDP); analysis of t-Pa; Analysis of Anisoylated Plasminogen Streptokinase Activated Complex (APSAC); analysis of amlodipine; analysis of alcohol and breast cancer; analysis of screening for maple syrup urine disease; analysis of nitrogen dioxide and respiratory illness in children; analysis of surveillance of colorectal cancer patients; analysis of colon cancer screening trial. Part 4 Implementation issues: sensitivity analysis; research planning; data collection and reporting; test case. Conclusions: other meta-analysis methods; summary and conclusions.