Medicinal Chemistry

Medicinal Chemistry : A Biochemical Approach

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The molecular action of drugs is emphasized in this text, which has been updated to incorporate the most recent research findings of biochemical pharmacology and the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action - endogenous messengers and their receptors, membranes, enzymes, and DNA, among others - and covers all the drug groups and their therapeutic applications. This thorough revision provides expanded coverage of co-transmitters and neuro-hormones, as well as adenosine receptors and calcium channel blockers. New topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumour and antibacterial agents. Undergraduate students, especially in pharmacology, and pharmacy more

Product details

  • Hardback | 530 pages
  • 150 x 230mm | 908g
  • Oxford University Press Inc
  • New York, United States
  • English
  • Revised
  • 2nd Revised edition
  • 175figs.46tabs.
  • 0195053680
  • 9780195053685

Table of contents

PHYSIOCHEMICAL PRINCIPLES OF DRUG ACTION: Role and structure of water; Solubility; Partition coefficients; Surface activity and drug effects; Stereochemical aspects of drug action; Quantitative structure-activity relationships; RECEPTOR-EFFECTOR THEORIES: The receptor concept and its history; The nature of receptors and the criteria of receptor identity; Definition of pharmacological binding terms; Classical theories of concentration-response relationships; Molecular concepts of receptor function; METHODS OF RECEPTOR CHARACTERIZATION: Methodological principles; Indirect methods of receptor characterization; Direct methods of receptor characterization; Data treatment; DRUGS ACTING ON NEUROTRANSMITTERS AND THEIR RECEPTORS: Outline of neuroanatomy and neurophysiology; Acetylcholine and the cholinergic receptors; Norepinephrine and the andrenergic receptors; Dopamine and the dopaminergic receptors; Serotonin and the serotonergic drug effects; Histamine and the histamine receptors; Purinergic neuromodulation and the adenosine receptors; Aminoacid neurotransmitters and the drug effects they mediate; DRUGS ACTING ON HORMONES, NEUROHORMONES, AND THEIR RECEPTORS: Steroid hormones and their receptors; Peptide and protein hormones and neurohormones; Enkephalins, endorphins, and opiate analgesics; Prostaglandins and thromboxanes; Atrial natriuretic factors; NON-MESSENGER TARGETS FOR DRUG ACTION: Excitable membranes; Cell-wall synthesis inhibitors; Enzymes as drug targets; Vitamins; Nucleic acids as targets for drug action; DRUG DISTRIBUTION AND METABOLISM: Drug distribution; Drug metabolism; PRINCIPLES OF DRUG DESIGN: Analogue synthesis versus rational design; Discovery of 'Lead' compounds; Pharmacophore identification; Pro-drugs and 'soft' drugs; Appendix: Drugs arranged by pharmacological activity; more

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