Medicinal Chemistry

Medicinal Chemistry : The Role of Organic Chemistry in Drug Research

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This Second Edition covers exciting progress recently made with individual drugs and includes a special chapter on the impact of molecular biology on drug design. Other additions to the Second Edition include structure-activity relationships, the role of molecular biology in drug discovery, and drug access and prodrugs. Written for students considering a research career in drug development, this volume is conveniently divided into two parts. The first half introduces readers to the mechanisms of action of drugs and the approaches adopted in designing new drugs. The second half contains chapters written by the discoverers or developers of individual successful drugs who trace the history of the drugs to the present day.
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Product details

  • Hardback | 368 pages
  • 170 x 246 x 22mm | 698.53g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • 012274120X
  • 9780122741203

Review quote

From the Review of the First Edition
"This book provides thorough and readable accounts of drug discovery by persons directly involved and should find use among students of medicinal chemistry and organic chemists wanting to learn more about how drugs are developed."
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Table of contents

1. Introduction to Receptors and the Action of Drugs
2. Structure and Atalytic Properties of Enzymes
3. Receptor Pharmacology
4. Drug Access and Prodrugs
5. QSAR and the Role of Computers in Drug Design
6. The Current Status and Future Impact of Molecular Biology in Drug Discovery
7. General Approaches to Discovering New Drugs: An Historical Perspective.
8. Discovery and Development of Cromakalim and Related Potassium Channel Activators
9. Angiotension-Converting Enzyme (ACE) inhibitors and the Design of Cilazapril
10. Beta Blockers
11. Salbutamol: A Selective B2-Stimulant Bronchodilator
12. Discovery of CCimetidine, Ranitidine and Other H2-Receptor Histamine Antagonists
13. Fluconazole, An Orally Active Antifungal Agent
14. Clavulanic Acid and Related Compounds: Inhibitors of B-Lactamase Enzymes
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