Medical Epigenetics

Medical Epigenetics

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Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume.
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Product details

  • Hardback | 924 pages
  • 191 x 235 x 50.8mm | 2,720g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128032391
  • 9780128032398
  • 1,396,335

Table of contents

Section I: Overview

1. An Overview of Medical Epigenetics Trygve O. Tollefsbol

Section II: Basic Principles of Epigenetics

2. DNA Methylation: Basic Principles Cynthia A. Moylan and Susan K. Murphy

3. Histone-deacetylases as a therapeutic target in neurodegenerative diseases Farahnaz Sananbenesi and Andre Fischer

4. Basic principles of noncoding RNAs in epigenetics Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani

Section III: General Medical Aspects of Epigenetics

5. Epidemiological Epigenetics in Medicine Alexander Vaiserman

6. Lifestyle and Preventive Medical Epigenetics Marcus V. Gomes

7. Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products Rachel L. Miller

8. Behavioral Medical Epigenetics Olivia H. Cox and Richard S. Lee

9. Medical Epigenetics in Twins Joel C. Eissenberg

10. Epigenetic Biomarkers of Disease Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam

11. Prognostic Epigenetics Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja

Section IV: Epigenetics of System Disorders

12. Immune System Disorders and Epigenetics Stuti Mehta and Kate L. Jeffrey

13. Pulmonary Diseases and Epigenetics Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen

14. Cardiovascular Disorders and Epigenetics Charbel Abi Khalil

15. Epigenomics of Intestinal Disease Daniel Rory Kelly and Theresa Alenghat

16. Epigenetics of Skin Disorders Shuaihantian Luo and Qianjin Lu

17. Epigenetics in Bone and Joint Disorders N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh

18. Epigenetics of Muscle Disorders Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo

19. Epigenetics of Psychiatric Disorders Marija Kundakovic

20. Epigenetic Alterations in Endocrine-dependent Cancers: Implications of Endocrine Dysfunctions Genevieve Deblois and Mathieu Lupien

21. Reproductive Disease Epigenetics Rafael Oliva*

22. Epigenetics in Ocular Medicine Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs*

Section V: Multi-system Medical Epigenetics

23. Pediatric Diseases and Epigenetics Judith G. Hall*

24. Epigenetics of Infectious Diseases Kate L. Seib and Michael P. Jennings

25. Clinical Utility of Solid Tumor Epigenetics Soren Kristiansen and Gyoergy Soeletormos

26. Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma Zeus Andrea Antonello and Carmelo Nucera

27. Epigenetics in Acute Myeloid Leukemia Cristina Giorgio, Carmela Dell'Aversana and Lucia Altucci

28. Epigenetic Regulation in Cancer Metastasis Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen

29. Epigenetics in Exercise Science and Sports Medicine Philipp Zimmer, Alexander Schenk and Wilhelm Bloch

30. Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes

Section VI. Pharmacology of Epigenetics

31. Toxicology and Epigenetics Jian Tajbakhsh and Jatinder Singh

32. Pharmacoepigenomics Ramon Cacabelos and Clara Torrellas

Section VII: Therapeutic Epigenetics

33. Therapeutics and DNA Methylation Inhibitors Sheena Bhalla and Shyamala C. Navada

34. Histone Deacetylase Inhibitors in Medical Therapeutics Pusoon Chun

35. NAD+-dependent Deacetylases and Medical Therapy Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg*

36. Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics H. Wapenaar and Frank J. Dekker

37. Histone Methylation Modifiers in Medical Therapeutics Patrick Trojer 38. Therapeutics of Epigenetic-based RNA molecules Costas Koufaris* and Vicky Nicolaidou

39. Natural Epigenetic-modifying Molecules in Medical Therapy Avinash Kumar, Nasir A. Butt and Anait S. Levenson

40. Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic Paromita Raha

41. Epigenetics of Pain Management Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney

42. Personalized Epigenetics Michael Bitzer and Nisar P. Malek

43. Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives Constantin Heil and Daniela Palacios

44. Stem Cell Epigenetics in Medical Therapy Baoli Cheng, Liqi Shu and Peng Jin

Section VIII: Medical Epigenetics: Future Prospects

45. Prospective Advances in Medical Epigenetics Junjie Xiao and Guoping Li
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About Trygve Tollefsbol

Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol's research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women's Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biotechnology and Clinical Epigenetics. He is also a contributing Editor of Lewin's GENES X classic textbook. Over 25 of the publications from Dr. Tollefsbol's laboratory have received national or international accolades such as best paper award, selection for press release by the journal editors and featured on the journal homepage. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, France and The Netherlands as well as at various leading institutions in the US such as Harvard Medical School, Tufts University and the University of California at San Francisco. His research has received considerable media attention both nationally and internationally through television, newspaper and radio venues and has been highlighted in eScience News and ScienceDaily. He has ten books which have been published or are in progress and a recent book on "Epigenetics of Aging" that Dr. Tollefsbol co-authored and edited was highlighted in Nature.
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