The Maudsley Prescribing Guidelines in Psychiatry
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The Maudsley Prescribing Guidelines in Psychiatry

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The revised 13th edition of the essential reference for the prescribing of drugs for patients with mental health disorders


The revised and updated 13th edition of The Maudsley Prescribing Guidelines in Psychiatry provides up-to-date information, expert guidance on prescribing practice in mental health, including drug choice, treatment of adverse effects and how to augment or switch medications. The text covers a wide range of topics including pharmacological interventions for schizophrenia, bipolar disorder, depression and anxiety, and many other less common conditions. There is advice on prescribing in children and adolescents, in substance misuse and in special patient groups.


This world-renowned guide has been written in concise terms by an expert team of psychiatrists and specialist pharmacists. The Guidelines help with complex prescribing problems and include information on prescribing psychotropic medications outside their licensed indications as well as potential interactions with other medications and substances such as alcohol, tobacco and caffeine. In addition, each of the book s 165 sections features a full reference list so that evidence on which guidance is based can be readily accessed. This important text:




Is the world s leading clinical resource for evidence-based prescribing in day-to-day clinical practice and for formulating prescribing policy
Includes referenced information on topics such as transferring from one medication to another, prescribing psychotropic medications during pregnancy or breastfeeding, and treating patients with comorbid physical conditions, including impaired renal or hepatic function.
Presents guidance on complex clinical problems that may not be encountered routinely


Written for psychiatrists, neuropharmacologists, pharmacists and clinical psychologists as well as nurses and medical trainees, The Maudsley Prescribing Guidelines in Psychiatry are the established reference source for ensuring the safe and effective use of medications for patients presenting with mental health problems.
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Product details

  • Paperback | 872 pages
  • 172 x 241 x 31mm | 1,228g
  • Wiley-Blackwell
  • Hoboken, United States
  • English
  • 13th Edition
  • 1119442605
  • 9781119442608
  • 8,224

Back cover copy

The revised 13th edition of the essential reference for the prescribing of drugs for patients with mental health disorders

The revised and updated 13th edition of The Maudsley Prescribing Guidelines in Psychiatry provides up-to-date, expert guidance on prescribing practice in mental health, including drug choice, treatment of adverse effects and how to augment or switch medications. The text covers a wide range of topics including pharmacological interventions for schizophrenia, bipolar disorder, depression and anxiety, and many other less common conditions. There is advice on prescribing in children and adolescents, in substance misuse and in special patient groups.

This world-renowned guide has been written in concise terms by an expert team of psychiatrists and specialist pharmacists. The Guidelines help with complex prescribing problems and include information on prescribing psychotropic medications outside their licensed indications as well as potential interactions with other medications and substances such as alcohol, tobacco and caffeine. In addition, each of the book's sections features a full reference list so the evidence on which guidance is based can be readily accessed. This important text: Is the world's leading clinical resource for evidence-based prescribing in day-to-day clinical practice and for formulating prescribing policy Includes referenced information on topics such as transferring from one medication to another, prescribing psychotropic medications during pregnancy or breastfeeding, and treating patients with comorbid physical conditions, including impaired renal or hepatic function Presents guidance on complex clinical problems that may not be encountered routinely

Written for psychiatrists, neuropharmacologists, pharmacists and clinical psychologists as well as nurses and medical trainees, The Maudsley Prescribing Guidelines in Psychiatry are the established reference source for ensuring the safe and effective use of medications for patients experiencing mental health problems.

Praise for previous editions:

'The Guidelines proves to be clinically useful and also accomplishes something larger. It lays out the ground rules for psychotropic prescribing without taking liberties that obfuscate the limits of our evidence... Thus, the Guidelines offers a different and refreshing perspective on prescribing, one that suggests that evidence-based, sometimes algorithmic, practices are possible, but that in situations within, and especially outside, those algorithms, decision-making is in the hands of the provider, sensitive to the patient's needs and values.'

The Journal of Clinical Psychiatry

'An excellent book and a "must" for practising psychiatrists... not only will the rational prescribing of psychotropic drugs drastically improve, but, more importantly, the patient will certainly benefit.'

Human Psychopharmacology

'I would regard this book as mandatory for any pharmacist directly involved in the care of patients with a psychiatric diagnosis, be they primary or secondary carer-based.'

The Pharmaceutical Journal
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Table of contents

Part 1: Drug treatment of major psychiatric conditions


Chapter 1: Schizophrenia and related psychoses


ANTIPSYCHOTIC DRUGS


General introduction


General principles of prescribing


Minimum effective doses


Licensed maximum doses


Equivalent doses


High-dose antipsychotics: prescribing and monitoring


Combined antipsychotics


Antipsychotic prophylaxis


Negative symptoms


Monitoring


Relative adverse effects a rough guide


Treatment algorithms for schizophrenia


First-generation antipsychotics place in therapy


NICE guidelines for the treatment of schizophrenia


Antipsychotic response to increase the dose, to switch, to add or just wait what is the right move?


Acutely disturbed or violent behaviour


Antipsychotic long-acting injections


Depot antipsychotics pharmacokinetics


Management of patients on long-term depots


Aripiprazole long-acting injection


Olanzapine long-acting injection


Paliperidone palmitate long-acting injection


Risperidone long-acting injection


Omega-3 fatty acid (fish oils) in schizophrenia


ANTIPSYCHOTIC ADVERSE EFFECTS


Extrapyramidal symptoms


Akathisia


Weight gain


Treatment of antipsychotic-induced weight gain


Electroconvulsive therapy and psychosis


Neuroleptic malignant syndrome


Catatonia


QT prolongation


Dyslipidaemia


Diabetes and impaired glucose tolerance


Blood pressure changes


Hyponatraemia


Hyperprolactinaemia


Sexual dysfunction


Pneumonia


Switching antipsychotics


Venous thromboembolism


REFRACTORY SCHIZOPHRENIA AND CLOZAPINE


Clozapine initiation schedule


Optimising clozapine treatment


Alternatives to clozapine


Re-starting clozapine after a break in treatment


Initiation of clozapine for community-based patients


CLOZAPINE ADVERSE EFFECTS


Clozapine: common adverse effects


Clozapine: uncommon or unusual adverse effects


Clozapine: serious haematological and cardiovascular adverse effects


Clozapine-induced hypersalivation


Clozapine-induced gastrointestinal hypomotility (CIGH)


Clozapine, neutropenia and lithium


Clozapine and chemotherapy


Chapter 2: Bipolar disorder


Lithium


Valproate


Carbamazepine


Antipsychotic drugs in bipolar disorder


Antipsychotic long-acting injections in bipolar disorder


Physical monitoring for people with bipolar disorder


Treatment of acute mania or hypomania


Rapid-cycling bipolar disorder


Bipolar depression


Prophylaxis in bipolar disorder


Chapter 3: Depression and anxiety disorders


Chapter 4 Addictions and substance misuse


Introduction


Alcohol dependence


Opioid dependence


Nicotine and smoking cessation


Pharmacological treatment of dependence on stimulants


GHB and GBL dependence


Benzodiazepine misuse


Synthetic cannabinoid receptor agonists (SCRAs)


Interactions between street drugs and prescribed psychotropic drugs


Drugs of misuse a summary


Part 2: Drug treatment of special patient groups


Chapter 5 Children and adolescents


Principles of prescribing practice in childhood and adolescence


Depression in children and adolescents


Bipolar illness in children and adolescents


Psychosis in children and adolescents


Anxiety disorders in children and adolescents


Obsessive compulsive disorder (OCD) in children and adolescents


Post-traumatic stress disorder in children and adolescents


Attention deficit hyperactivity disorder


Autism spectrum disorders


Tics and Tourette s syndrome


Melatonin in the treatment of insomnia in children and adolescents


Rapid tranquillisation (RT) in children and adolescents


Doses of commonly used psychotropic drugs in children and adolescents


Chapter 6 Prescribing in older people


General principles


Dementia


Safer prescribing for physical conditions in dementia


Management of behavioural and psychological symptoms of dementia


A guide to medication doses of commonly used psychotropic drugs in older adults


Covert administration of medicines within food and drink


Chapter 7: Pregnancy and breastfeeding


Drug choice in pregnancy


Breastfeeding


Chapter 8: Hepatic and renal impairment


Hepatic impairment


Renal impairment


Part 3: Prescribing in specialist conditions


Chapter 9: Drug treatment of other psychiatric conditions


Borderline personality disorder


Eating disorders


Delirium


Chapter 10: Drug treatment of psychiatric symptoms occurring in the context of other disorders


General principles of prescribing in human immunodeficiency virus (HIV)


Prescribing psychotropics in HIV


Epilepsy


22q11.2 Deletion syndrome


Learning disabilities


Huntington s disease


Multiple sclerosis


Parkinson s disease


Atrial fibrillation


Bariatric surgery


Part 4: Other aspects of psychotropic drug use


Chapter 11 Pharmacokinetics


Plasma level monitoring of psychotropic drugs


Interpreting post-mortem blood concentrations


Acting on clozapine plasma concentration results


Psychotropic drugs and cytochrome (CYP) function


Smoking and psychotropic drugs


Drug interactions with alcohol


Chapter 12 Other substances


Caffeine


Nicotine


Chapter 13: Psychotropic drugs in special conditions


Psychotropic drugs in overdose


Driving and psychotropic drugs


Psychotropic drugs and surgery


Chapter 14: Miscellany


Enhancing medication adherence


Re-starting psychotropic medications after a period of non-compliance


Biochemical and haematological effects of psychotropic medications


Summary of psychiatric adverse effects of non-psychotropic medications


Prescribing drugs outside their licensed indications ( off-label prescribing)


The Mental Health Act in England and Wales


Site of administration of intramuscular injections
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About David M. Taylor

David M. Taylor BSc, MSc, PhD, FFRPS, FRPharmS, is Director of Pharmacy and Pathology at the Maudsley Hospital and Professor of Psychopharmacology at King's College, London.


Thomas R. E. Barnes, MBBS, MD, FRCPsych, DSc, is Emeritus Professor of Clinical Psychiatry at Imperial College London and joint-head of the Prescribing Observatory for Mental Health at the Royal College of Psychiatrists' Centre for Quality Improvement.


Allan H. Young, MB, ChB, MPhil, PhD, FRCPC, FRCPsych, is Chair of Mood Disorders and is Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry at King's College London, UK.
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