Mass Spectrometry

Mass Spectrometry : Techniques for Structural Characterization of Glycans

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Description

Mass Spectrometry: Techniques for the Structural Characterization of Glycans presents new methods for conducting detailed carbohydrate qualitative analysis-arming analytical chemists, pharmaceutical scientists, and food scientists with a quick reference that will allow them to determine the structures of carbohydrates molecules.

As there is a need in the scientific community for content specific to structural determination and analysis of new glycoprotein drug, and because structure-activity analysis requires a structural determination of the N- and O-linked oligosaccharides linked to glycol-proteins, this book provides the relevant research that are necessary for advances and new outcomes in this area of study.
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Product details

  • Hardback | 86 pages
  • 152 x 229 x 10.16mm | 320g
  • United States
  • English
  • black & white illustrations
  • 0128041293
  • 9780128041291

Table of contents

* Introduction
* Monosaccharide Composition Analysis
* Elemental Analysis of MS Ions
* Derivatization Techniques
* Hydride Addition to Sulfate and phosphate- Chemistry
* Instrumentation
MALDI-TOF MS
API 2000 MS
ICP ESI TOF MS
* Hydride Insertion Addition Reaction for the Derivatization of Phosphorylated or Sulfated Glycans and the Discernment of Phosphate versus Sulfate Esters
* Ester Substitution MS Method
The Protocol for the Hydride Addition to the ethanol extract of banana fruit
Example of MS2on Hydride added to the ethanol Extract of Banana Fruit Glycan
* Glycan Isolation Methods
* Other Glycan isolation Methods
* Monosaccharide Analysis
Acid Hydrolysis
* Mass Spectral Carbohydrate Structure Determination Method
MS
MS/MS (MS2)
MSn
Proposing Initial Structure
Refining Methods for Determining Exact Mass Structure
MS Instrumentation Requirements for Discovering Whole Molecule Ions
Derivatization Method and Sulfate/Phosphate Discernment Method
* References
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About Michael A. Madson

Mike Madson is CEO and Senior Research Scientist of BioLogistics, LLC, Iowa, USA
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