Malignancy and Chronic Inflammation in the Gastrointestinal Tract - New Concepts

Malignancy and Chronic Inflammation in the Gastrointestinal Tract - New Concepts

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Despite recent advances, the pathogenesis and therapy of various forms of chronic inflammatory diseases of the gastrointestinal tract remains problematical. Especially threatening is the possible complication of the development of a malignant growth, but the role of the chronic inflammatory process in this is not known. Three examples are: H. pylori-induced gastritis is associated with gastric lymphomas and carcinomas; there is an increased incidence of intestinal T-cell lymphomas in tropical sprue; and chronic inflammatory bowel diseases, particularly ulcerative colitis, are associated with an increased incidence of carcinoma.
In this book, the Proceedings of Falk Symposium No. 81, held in Berlin, November 3-5, 1994, an extensive exchange of information and opinions between international experts yields a state-of-the-art consensus on practical procedures in diagnostics, prophylaxis and therapy.
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Product details

  • Hardback | 178 pages
  • 155.96 x 233.93 x 11.18mm | 433g
  • Dordrecht, Netherlands
  • English
  • 1995 ed.
  • 178 p.
  • 0792388895
  • 9780792388890

Table of contents

List of principal authors. Introduction. Section I: Helicobacter pylori and malignant transformation. Helicobacter pylori infection - clinical aspects and epidemiology; M. Gregor. Helicobacter pylori: mechanisms of pathogenicity; J.-D. Schulzke, et al. Significance of Helicobacter pylori infection for malignant transformation of epithelial cells; M. Stoltes, S. Eidt. Cytokine responses to Helicobacter pylori infection; J.E. Crabtree. The role of Helicobacter pylori in the pathogenesis of primary gastric B-cell lymphoma; P.G. Isaacson. In vitro studies of malignant B cells from low grade B cell gastric lymphoma of mucosa associated lymphoid tissue; T. Hussell, et al. Section II: Coeliac disease and enteropathy-associated lymphomas. Clinical and pathological spectrum of coeliac disease; A. Ferguson, et al. Genetic susceptibility to coeliac disease; M.F. Kagnoff. Phenotype and functions of intraepithelial lymphocytes; N. Cerf-Bensussan, D. Guy-Grand. T cell mediated mucosal transformation; T.T. MacDonald, et al. Genetic events in colon carcinoma; K. Moelling, et al. Section III: Inflammatory bowel disease and malignancy. Intestinal cancer risk in patients with inflammatory bowel disease; V. Binder, et al. Incidence and significance of dysplasia in ulcerative colitis; R.H. Riddell. Endoscopic surveillance in ulcerative colitis; J. Lennard-Jones. Phenotypic and clinicopathological peculiarities of mucinous colonic carcinoma; C. Hanski, et al. Value of flow cytometry in the surveillance of patients with ulcerative colitis; R. Porschen, et al. Molecular biology of colitis-associated neoplasia; S.J. Meltzer, B.G. Greenwald. Index.
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