Macromolecular Drug Delivery
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Macromolecular Drug Delivery : Methods and Protocols

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Description

Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology (TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.
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Product details

  • Hardback | 205 pages
  • 157.48 x 236.22 x 17.78mm | 430.91g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2009 ed.
  • 14 Tables, black and white; XIV, 205 p.
  • 1588299996
  • 9781588299994

Review quote

From the reviews:

"This volume ... provides details and discussions on contemporary methods available to address the limitations in the delivery of these agents. ... This comprehensive review will be of interest to scientists investigating either the in vitro or in vivo actions of macromolecule agents. Experts in biophysics, chemistry, cell biology, pharmaceutics, and/or preclinical and clinical dug discovery studies will find this book of value. Researchers involved in target therapy strategies for treatment of diseases will want a copy of this book." (Thomas L. Pazdernik, Doody's Review Service, 2009)
"The title of the book will definitely attract readers of various backgrounds. It seems to indicate that the book covers the delivery of various kinds of macromolecular drugs. ... This will come as a surprise for experts working with other types of macromolecular therapeutics ... . the in vitro and in vivo models described in the book would be of interest to a broad scientific audience. ... the book definitely contains a lot of valuable information for experimental researchers." (Michal Pechar, ChemMedChem, Issue 4, 2009)
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Back cover copy

Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology(TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.



Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.
show more

Table of contents

Macromolecular Drug Delivery
Dr. Mattias Belting, ed.


Table of Contents
Preface
Contributors


Developments in Macromolecular Drug Delivery; Review Chapter

Mattias Belting and Anders Wittrup

Synthetic vs. Natural/Biodegradable Polymers for Delivery of shRNA Based Cancer Therapies; Review chapter

John S. Vorhies and John J. Nemunaitis

siRNA and DNA Transfer to Cultured Cells

Bagavathi Gopalakrishnan and Jon Wolff

Poly(ss-amino esters): Procedures for Synthesis and Gene Delivery

Jordan J. Green, Gregory T. Zugates, Robert Langer, and Daniel G. Anderson

Systemic Delivery and Preclinical Evaluation of Nanoparticles Containing Antisense Oligonucleotides and siRNAs

Chuanbo Zhang, Joseph T. Newsome, Rajshree Mewani, Jin Pei, Prafulla C. Gokhale, and Usha N. Kasid

Peptide-based Delivery of Steric-block PNA Oligonucleotides

Said Abes, Gabriela D. Ivanova, Rachida Abes, Andrey A. Arzumanov, Donna Williams, David Owen, Bernard Lebleu and Michael J. Gait

Characterizing Peptide Mediated DNA Internalization in Human Cancer Cells

Anders Wittrup and Mattias Belting

Selection and Characterization of Antibodies from Phage Display Libraries against Internalizing Membrane Antigens

Johan Fransson and Carl A. K. Borrebaeck

Artificial Membrane Models for the Study of Macromolecular Delivery

Lena Maler and Astrid Graslund

Enhanced Delivery of Macromolecules into Cells by Electroendocytosis

Alexander Barbul, Yulia Antov, Yosef Rosenberg and Rafi Korenstein

In Vitro Systems for Studying Epithelial Transport of Macromolecules

Nicole Daum, Andrea Neumeyer, BirgitWahl, Michael Bur, Claus-Michael Lehr

Preparation of Macromolecule-containing Dry Powders for Pulmonary Delivery

Kelly S. Kraft and Marshall Grant

Macromolecular Delivery Across the Blood-Brain Barrier

Kullervo Hynynen

Positron Emission Tomography (PET) and Macromolecular Delivery In Vivo

Ludwig G. Strauss and Antonia Dimitrakopoulou-Strauss
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Review Text

From the reviews:

"This volume ... provides details and discussions on contemporary methods available to address the limitations in the delivery of these agents. ... This comprehensive review will be of interest to scientists investigating either the in vitro or in vivo actions of macromolecule agents. Experts in biophysics, chemistry, cell biology, pharmaceutics, and/or preclinical and clinical dug discovery studies will find this book of value. Researchers involved in target therapy strategies for treatment of diseases will want a copy of this book." (Thomas L. Pazdernik, Doody's Review Service, 2009)
"The title of the book will definitely attract readers of various backgrounds. It seems to indicate that the book covers the delivery of various kinds of macromolecular drugs. ... This will come as a surprise for experts working with other types of macromolecular therapeutics ... . the in vitro and in vivo models described in the book would be of interest to a broad scientific audience. ... the book definitely contains a lot of valuable information for experimental researchers." (Michal Pechar, ChemMedChem, Issue 4, 2009)
show more