Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

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Description

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters.

Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition.
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Product details

  • Hardback | 276 pages
  • 216 x 276 x 17.53mm | 1,040g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128038098
  • 9780128038093

Table of contents

1. Junctional Interplay in Lung Epithelial Barrier Function 2. Ion Transport and Lung Fluid Balance 3. Glucose Transport and Homeostasis in Lung Epithelia 4. Pulmonary Surfactant Trafficking and Homeostasis 5. Integrin Regulation of the Lung Epithelium 6. Epithelial Regeneration and Lung Stem Cells 7. The Function of Epithelial Cells in Pulmonary Fibrosis 8. The Role of Epithelial Cell Quality Control in Health and Disease of the Distal Lung 9. The Respiratory Epithelium in COPD 10. Acute Respiratory Distress Syndrome 11. Epithelial Barrier Dysfunction in Asthma 12. Cystic Fibrosis: An Overview of the Past, Present, and the Future
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Review Text

"...a very comprehensive book that deals with the lung epithelial biology and molecular signaling involved in the normal lung and their implications in disease pathogenesis. It is very well written by experts in the field, highly illustrated, and presented in a very readable format. It is highly recommended for any clinician or scientist who is interested in the molecular and cellular workings of the lung. Score: 92 - 4 Stars" -- Doody's
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Review quote

"...a very comprehensive book that deals with the lung epithelial biology and molecular signaling involved in the normal lung and their implications in disease pathogenesis. It is very well written by experts in the field, highly illustrated, and presented in a very readable format. It is highly recommended for any clinician or scientist who is interested in the molecular and cellular workings of the lung. Score: 92 - 4 Stars" --Doody's
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About Michael Koval

Dr. Sidhaye is an Associate Professor at Johns Hopkins University School of Medicine. Her laboratory is interested in studying lung epithelial cellular responses in chronic lung disease, with a focus on cytoskeleton and cell-cell adhesion. The long term goal is determining lung epithelial responses in COPD and identifying if these changes promote disease and whether we can identify targets to reverse disease. Dr. Koval's laboratory works on defining the molecular machinery that regulates formation of gap junctions (which coordinate intercellular signaling) and tight junctions (which promote tissue barrier function). The long term goal of his research is understanding how junctions are pathologically misregulated in lung injury and in diseases including alcoholic lung syndrome, acute respiratory distress syndrome and cystic fibrosis.
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