Liver Regeneration and Carcinogenesis

Liver Regeneration and Carcinogenesis : Molecular and Cellular Mechanisms

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This work synthesizes current research into mechanisms of carcinogenesis and cell growth. Because of its ability to regenerate, many researchers use the liver as a model system to study these and other phenomena. Recently, advances have occurred in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This work brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis and liver tumour therapy.
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Product details

  • Hardback | 383 pages
  • 159 x 235 x 26mm | 763g
  • Academic Press Inc
  • San Diego, United States
  • English
  • illustrations, index
  • 0123853559
  • 9780123853554

Table of contents

Liver regeneration, then and now, N.L.R. Bucher; hepatocyte growth factoe (HGF) and its receptor (MET) in liver regeneration, neoplasia, and disease, G.K. Michalopoulos; structure and functions of the HGF receptor (c-Met), P.M. Comoglio and E. Vigna; expression and function of growth-induced genes during liver regeneration, R.Taub; stem cells and hepatocarcinogenesis, S.S. Thorgeirsson; contributions of hepadnavirus research to our understanding of hepatocarcinogenesis, C.E. Rogler et al; apoptosis and hepatocarcinogenesis, R. Schulte-Hermann et al; liver tumour promotion and the suppression of p53-dependent cell cycle checkpoint function, Y. Zhang et al; mechanisms of liver tumour promotion, J.J. Mills et al; hypomethylation of DNA - a epigenetic mechanism that can facilitate the aberrant oncogene expression involved in liver carcinogenesis, J.L. Counts and J.I. Goodman; transgene-based strategies for studying liver growth, development, and cancer, E.P. Sandgren
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