Liver Pathophysiology

Liver Pathophysiology : Therapies and Antioxidants

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Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants.

Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.
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Product details

  • Hardback | 914 pages
  • 216 x 276 x 48.26mm | 2,790g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128042745
  • 9780128042748

Table of contents

Section I. Introduction 1. The Liver: General Aspects and Epidemiology 2. Structure and Ultrastructure of the Normal and Diseased Liver

Section II. Liver Pathophysiology 3. Hepatic Apoptosis and Necrosis: Mechanisms and Clinical Relevance 4. Autoimmune Hepatitis 5. Pathogenesis of Idiosyncratic Drug Induced Liver Injury 6. Acetaminophen 7. Liver Regeneration 8. Nitric Oxide in Liver Ischemia-Reperfusion Injury 9. The Immune System and Viral Hepatitis 10. The Pathophysiology of Alcoholic Liver Disease 11. Cytokines in Steatohepatitis 12. Redox Signaling in NASH 13. Amebic Liver Abscess 14. Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica 15. Epigenetics in Liver Disease: Involvement of Oxidative Stress 16. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis 17. Oxidative and Nitrosative Stress in Chronic Cholestasis 18. Cholestasis, Contraceptives, and Free Radicals 19. Is Human Cirrhosis a Reversible Disease? 20. Obesity and Hepatocellular Carcinoma 21. Oxidative Stress as a Mechanism for Hepatocellular Carcinoma 22. Nuclear Factor-Kappa B Actions During the Development of Hepatocellular Carcinoma 23. The Role of Senescence in Hepatic Diseases 24. Exercise, Liver Steatosis, and Free Radicals 25. The Metabolic Syndrome, Oxidative Stress, and the Liver 26. Liver Diseases in the Elderly 27. Cytokines in Hepatic Injury 28. Nrf2: A Key Regulator of Redox Signaling in Liver Diseases 29. Redox Regulation by HGF/c-Met in Liver Disease

Section III. Liver Metabolism 30. Hepatic Metabolism in Liver Health and Disease 31. Cytochrome P450 and Oxidative Stress in the Liver 32. Drug Hepatic Clearance in Spinal Cord Injury

Section IV. Cirrhosis and Its Complications 33. Complications of Cirrhosis: Introduction 34. Portal Hypertension-Molecular Mechanisms 35. Gastroesophageal Varices 36. Ascites 37. Reactive Nitrogen and Oxygen Species in Hepatic Encephalopathy 38. Hepatorenal Syndrome 39. Hepatopulmonary Syndrome and Portopulmonary Hypertension

Section V. Methods in Liver Disease 40. Experimental Models of Liver Damage Mediated by Oxidative Stress 41. Monitoring of Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis 42. In Vitro Models of HCC

Section VI. Therapies in Liver Disease 43. The Liver, Oxidative Stress, and Antioxidants 44. Herbal Drugs on the Liver 45. Silymarin for Liver Disease 46. Naringenin and the Liver 47. Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver 48. Coffee and the Liver 49. Hepatoprotective Properties of Curcumin 50. Retinoids in Liver Function 51. Stevia as a Putative Hepatoprotector 52. Are N-Acetylcysteine and Resveratrol Effective Treatments for Liver Disease? 53. Does Nutrition Matter in Liver Disease? 54. One-Carbon Metabolism in Liver Health and Disease 55. Ursodeoxycholic Acid for the Treatment of Liver Diseases 56. Current Treatment of Chronic Hepatitis C 57. An Adenosine Derivative Compound as a Hepatoprotective Agent 58. Nitric Oxide and the Liver 59. Repopulation of Cirrhotic Liver by Hepatic Stem/Progenitor Cells: A Promising Strategy Alternative to Liver Transplantation 60. Gene Therapy for Liver Disease 61. Role of Oxidative Stress in Liver Transplantation
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About Pablo Muriel

Dr. Muriel has research experience in the pathophysiology and pharmacology of liver diseases including necrosis, fibrosis and cholestasis; the role of cytokines in liver diseases; and oxidative stress and its relation to liver disease. He has published over 100 articles (original and reviews) in addition to 7 book chapters in the area of the liver and has also directed the thesis on dozens of postgraduate students in the same area over the last 30 years. The majority of his work has been in the Medicine and Pharmacology areas. He shows strong and growing citation counts from 2010-2017.
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