Liver Immunology

Liver Immunology : Principles and Practice

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Description

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. This volume is a must-read for novice and expert alike. In an easy-to-read and thorough format, it covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation.show more

Product details

  • Hardback | 501 pages
  • 210.82 x 276.86 x 30.48mm | 1,338.09g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2007.
  • 84 black & white tables, biography
  • 1588298183
  • 9781588298188
  • 2,413,340

Review quote

From the reviews: "We enjoyed reading this book because it contains much useful information and many interesting insights into liver immunology. The topic is of great interest because of continuing advances in our understanding of chronic viral infection of the liver, autoimmune liver disease, and liver transplantation. ... In summary, this book is a good attempt to provide broad coverage of liver immunology ... ." (Gideon Hirschfield and Jenny Heathcote, New England Journal of Medicine, April, 2008) "This book summarises the latest research on liver pathology and pathophysiology. ... There is an abundance of figures and tables, which are easy to understand, and a wide illustration of clinical applications that have been described in great detail. On the whole this is a very attractive book for students and medics who seek a comprehensive introduction into liver immunology and an update of the latest proceedings in clinical and translational research. I can therefore easily recommend this book for all liver enthusiasts." (York Aarbodem, Immunology News, November, 2008)show more

Back cover copy

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided. Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike.show more

Table of contents

LIVER IMMUNOLOGY: PRINCIPLES AND PRACTICE EDITORS: M. Eric Gershwin, M.D. John M. Vierling, M.D. Michael P. Manns, M.D. 2nd edition Correspondence to: M. Eric Gershwin, M.D., Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 E. Health Sciences Drive, Suite 6510, Davis, CA 95616; Telephone: 530-752-2884; Fax: 530-752-4669; Email: megershwin@ucdavis.edu Table of Contents Foreward Contemporary Liver Immunology and Immunopathology: Obstacles and Opportunuties Ian R. Mackay, MD, FRCP, FRACP, VRCPA, FAA Preface Clinical Use of Immunosuppressive Drugs to Control the Immune Response John Vierling, M.D., F.A.C.P. Chapter 1: A Short Primer of Fundamental Immunology Cliona O'Farrelly, Ph.D. Derek G. Doherty, Ph.D. Chapter 2: Role and Function of Liver Sinusoidal Endothelial Cells Percy A. Knolle, M.D. Chapter 3: Innate Immune Mechanisms in the Liver Cliona O'Farrelly, Ph.D. Derek G. Doherty, Ph.D. Chapter 4: Antigen Processing and Presentation in the Liver Masanori Abe, M.D., Ph.D. Angus W. Thomson, Ph.D., DSc Chapter 5: Adaptive Immunity in the Liver James D. Gorham, M.D., Ph.D. Chapter 6: Hepatic NK, NKT and T Cells Golo Ahlenstiel, M.D. Barbara Rehermann, M.D. Chapter 7: Cytokines in Liver Health and Disease Pietro Invernizzi, M.D., Ph.D. Ilaria Bianchi, M.D. Massimo Locati, M.D. Raffaella Bonecchi, Ph.D. Carlo Selmi, M.D., Ph.D. Chapter 8: Prevalence and Significance of Autoantibodies in Acute and Chronic Liver Diseases and Hepatocellular Carcinoma Christian P. Strassburg, M.D. Chapter 9: The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis Wajahat Mehal, M.D., D. Phil. Scott L. Friedman, M.D. Chapter 10: Clinical Use of Immunopathology Techniques in Liver Diseases Chen Liu, M.D., Ph.D. James M. Crawford, M.D., Ph.D. Chapter 11: Tumor Immunology: Hepatocellular Carcinoma, Cholangiocarcinoma and Metastatic Neoplasms Christopher Bowlus, M.D. Bacterial, Parasitic and Viral Infections of the Liver Chapter 12: Innate and Adaptive Immune Responses to Bacterial and Parasite Infections: Clinicopathological Consequences Valentina Medici, M.D. Lorenzo Rossaro, M.D. Sripriya Balasubramanian, M.D. Stuart H. Cohen, M.D. Chapter 13: Immun Response to Hepatitis A and E Viruses: Role in Disease Pathogenesis and Viral Elimination Johannes Hadem, M.D. Chapter 14: Role of the Immune Response in Hepatitis B: Determinants of Severity,Chronicity, and Response to Antiviral Therapy Antonio Bertoletti Patrick Kennedy Adam J. Gehring Chapter 15 Immune Responses in Acute and Chronic Hepatitis C: Implications for Prognosis and Therapy Heiner Wedemeyer, Chapter 16: Immunopathogenesis of Extrahepatic Manifestations in HAV, HBV and HCV Infections: Importance of recognition and Therapy Michael Manns, Elmar Jaeckel, Autoimmune Liver Diseases Chapter 17: Immunogenetics of Autoimmune Liver Diseases: Risk Factors for Susceptibility and Progression Peter Tickell Donaldson, BSc, PhD Chapter 18: Primary Biliary Cirrhosis and Autoimmune Cholangitis Carlo Selmi, M.D., Ph.D. Ana Lleo, M.D. Pietro Invernizzi, M.D., Ph.D. M. Eric Gershwin, M.D. Chapter 19: Sclerosing Cholangitis Sue Cullins, BSc, MB, BS, MRCP MD Roger Chapman, BSc, MB, BS, FRCP, MD, MA Chapter 20: Autoimmune Hepatitis Diego Vergani, M.D., Ph.D. Giorgina Mieli-Vergani, M.D., Ph.D. Chapter 21: Unique Aspects of Autoimmune Hepatitis in Children Giorgina Mieli-Vergani, M.D., Ph.D. Diego Vergani, M.D., Ph.D. Chapter 22: Overlap Syndromes of Autoimmune Hepatitis with Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis Ulrich Beuers, M.D. Christian Rust, M.D. Chapter 23: Animal Models of Autoimmune Liver Diseases Markus Biburger, PhD Gisa Tiegs, PhD Alcoholic and nonalcoholic Fatty Liver Diseases Chapter 24: The Immune Response in the Pathogenesis of Alcoholic Liver Disease Lynell W. Klassen, M.D. Geoffrey Thiele, Ph.D. Chapter 25: Immunomodulatory Therapy for Severe Alcoholic Hepatitis: Rationale and Efficacy Arthur McCullough, Chapter 26: Role of Immune Response in Nonalcoholic Fatty Liver Diseases: Evidence in Human and Animal Studies Liu Yang, M.D. Anna Mae Diehl, M.D. Acute Liver Failure Chapter 27: Mechanisms of Acute Liver Failure Christian Trautwein, Alexander Koch, M.D. Hepatotoxicity of Medications Chapter 28: Immune Mechanisms in Drug-Induced Hepatotoxicity: Therapeutic Implications Zhang-Xu Liu, M.D., Ph.D. Neil Kaplowitz, M.D. Chapter 29: Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics Frank N.A.M. van Pelt, MSc, PhD Michelle A. Carey, PhD John B. Carey, PhD Transplantation Chapter 30: Clinical Use of Immunosuppressive Drugs to Control the Immune Response John M. Vierling, M.D., F.A.C.P. Chapter 31: Hepatic Complications of Hematopoietic Cell Transplantation Howard M. Shulman, M.D. George B. McDonald, M.D. Chapter 32: Acute and Chronic Rejection of the Liver Allograft James Neuberger, DM, FRCP Chapter 33: Immunologic Tolerance in Allo- and Xenografts Aftab A. Ansari, Ph.D. Kovit Pattanapanyasat, Ph.D. Chapter 34: Autoimmune Diseases in Transplanted Livers Hiromi Ishibashi, M.D. Shinji Shimoda, M.D. Minoru Nakamura, M.D. M. Eric Gershwin, M.D. Chapter 35: Immunopathogenesis and Outcomes of Recurrent Hepatitis C James R. Burton, Jr., M.D. Lucy Golden-Mason, Ph.D.show more