Liver Disease in Children

Liver Disease in Children

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The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
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Product details

  • Hardback | 752 pages
  • 224 x 282 x 40mm | 2,480g
  • Cambridge, United Kingdom
  • English
  • Revised
  • 4th Revised edition
  • 156 Tables, black and white; 146 Halftones, unspecified; 115 Halftones, color; 108 Line drawings, unspecified; 20 Line drawings, color
  • 1107013798
  • 9781107013797
  • 1,162,965

Table of contents

Preface; Part I. Pathophysiology of Pediatric Liver Disease: 1. Liver development Yiwei Zong and Joshua R. Friedman; 2. Functional development of the liver Frederick J. Suchy; 3. Mechanisms of bile formation and cholestasis Nitika A. Gupta and Saul J. Karpen; 4. Acute liver failure in children Robert H. Squires and Estella M. Alonso; 5. Cirrhosis and chronic liver failure Evelyn K. Hsu and Karen F. Murray; 6. Portal hypertension Benjamin L. Shneider; 7. Laboratory assessment of liver function and injury in children Vicky Lee Ng; Part II. Cholestatic Liver Disease: 8. Approach to the infant with cholestasis Amy Feldman and Frederick J. Suchy; 9. Medical and nutritional management of cholestasis in infants and children Andrew P. Feranchak, Frederick J. Suchy and Ronald J. Sokol; 10. Neonatal hepatitis and congenital infections Philip Rosenthal; 11. Biliary atresia and other disorders of the extrahepatic bile ducts William F. Balistreri, Jorge A. Bezerra and Frederick C. Ryckman; 12. Neonatal jaundice and disorders of bilirubin metabolism Mark Bartlett and Glenn R. Gourley; 13. Familial hepatocellular cholestasis Frederick J. Suchy, Shikha S. Sundaram and Benjamin L. Shneider; 14. Alagille syndrome Binita M. Kamath, Nancy B. Spinner and David A. Piccoli; 15. Intestinal failure associated liver disease Jason Soden and Ronald J. Sokol; 16. Disease of the gallbladder in infancy, childhood, and adolescence Frank W. DiPaola and James E. Heubi; Part III. Hepatitis and Immune Disorders: 17. Hepatitis A and hepatitis E virus infection Philip Rosenthal; 18. Hepatitis B virus infection Mei-Hwei Chang; 19. Hepatitis C virus infection Maureen M. Jonas; 20. Autoimmune hepatitis Nanda Kerkar and Cara L. Mack; 21. Sclerosing cholangitis Alexander G. Miethke and William F. Balistreri; 22. Drug-induced liver disease Eve A. Roberts; 23. Liver disease in immunodeficiencies Nedim Hadzic; Part IV. Metabolic Liver Disease: 24. Laboratory diagnosis of inborn errors of metabolism Piero Rinaldo; 25. 1-antitrypsin deficiency David H. Perlmutter; 26. Cystic fibrosis liver disease Meghana Sathe and Andrew P. Feranchak; 27. Inborn errors of carbohydrate metabolism Rana F. Ammoury and Fayez K. Ghishan; 28. Copper metabolism and copper storage disorders Ronald J. Sokol; 29. Iron storage disorders Michael R. Narkewicz and Peter F. Whittington; 30. Heme biosynthesis and the porphyrias Robert J. Desnick, Manisha Balwani and Karl E. Anderson; 31. Tyrosinemia Grant Mitchell, Pierre A. Russo, Josee Dubois and Fernando Alvarez; 32. Lysosomal storage disorders T. Andrew Burrow and Gregory A. Grabowski; 33. Disorders of bile acid synthesis and metabolism Kenneth D. R. Setchell; 34. Inborn errors of fatty acid oxidation Melanie B. Gillingham and Robert B. Steiner; 35. Mitochondrial hepatopathies Ronald J. Sokol; 36. Nonalcoholic fatty liver disease in children Rohit Kohli, Kevin E. Bove and Stavra A. Xanthakos; 37. Peroxisomal diseases Paul A. Watkins and Kathleen B. Schwarz; 38. Urea cycle disorders Derek Wong and Stephen Cederbaum; Part V. Other Considerations and Issues in Pediatric Hepatology: 39. Bacterial, parasitic, and fungal infections of the liver Donald A. Novak, Gregory Y. Lauwers and Richard L. Kradin; 40. Systemic disease and the liver Kathleen M. Campbell; 41. Fibrocystic liver disease Ronen Arnon, Maureen M. Jonas, Antonio R. Perez-Atayde and Frederick J. Suchy; 42. Tumors of the liver Dolores Lopez-Terrada and Milton J. Finegold; 43. Liver transplantation in children: indications and surgical aspects M. Kyle Jensen, Maria H. Alonso, Jaimie D. Nathan, Frederick C. Ryckman, Gregory M. Tiao and William F. Balistreri; 44. Liver transplantation in children: post-transplant care Estella M. Alonso and Riccardo A. Superina; Index.
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Review quote

Review of previous edition: 'The essential pediatric hepatology textbook.' New England Journal of Medicine Review of previous edition: 'Well written and organized ... builds on a strong scientific foundation and effectively bridges pathophysiologic principles with clinical practice, providing authoritative updated reviews on all topics relevant to the discipline. The textbook is the premier reference in the field and should be truly enjoyed by primary care practitioners, gastroenterologists, hepatologists, and anyone genuinely interested in the care of children with liver disease.' Journal of the American Medical Association Review of previous edition: 'The text is accompanied by an excellent selection of color plates and is generally well illustrated throughout ... the authors are to be congratulated for tapping the writing skills of some of the foremost experts in pediatric hepatology for the text.' Pediatric Gastroenterology
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About Frederick J. Suchy

Frederick J. Suchy, MD is Chief Research Officer and Director, The Children's Hospital Research Institute, Children's Hospital Colorado. He is also Professor of Pediatrics and Associate Dean for Child Health Research, University of Colorado School of Medicine, Aurora, CO, USA. Ronald J. Sokol, MD is Professor and Vice Chair of Pediatrics, Section Head, Gastroenterology, Hepatology and Nutrition, Director, Colorado Clinical and Translational Sciences Institute, and holds the Arnold Silverman MD Chair in Digestive Health, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA. William F. Balistreri, MD is Director Emeritus of the Pediatric Liver Care Center, Medical Director Emeritus, Liver Transplantation, and Dorothy M. M. Kersten Professor of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition at the Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
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