Lipophilicity in Drug Action and Toxicology

Lipophilicity in Drug Action and Toxicology

  • Electronic book text
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In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from leading experts. It offers a thorough and highly topical survey of this rapidly developing field of research. Color plates demonstrating structural aspects, a vast number of references, and the straightforward presentation of the material make this volume a invaluable tool for all researchers involved in drug design or in the investigation of drug action.
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Product details

  • Electronic book text | 463 pages
  • John Wiley and Sons Ltd
  • Wiley-VCH Verlag GmbH
  • United Kingdom
  • 3527614982
  • 9783527614981

Table of contents

Aus dem Inhalt: Lipophilicity: The empirical tool and the fundamental objective/ Lipophilicity: A history/ Thermodynamics of van der Waals and hydrophobic interactions/ Intramolecular interactions encoded in lipophilicity: their nature and significance/ Lipophilicity measurement by reversed-phase high performance liquid chromatography (RP-HPLC)/ Centrifugal partition chromatography for lipophilicity measurements/ Assessment of distribution - pH profiles/ Estimation of lipophilicty by reversed-phase thin layer chromatography/ The future of log P calculation/ Theoretical calculation of partition coefficients/ Cellular automata model of partitioning between liquid phases
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