Lipid Mediators

Lipid Mediators

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The structural identification of lipid mediators such as platelet activating factor and the leukotrienes has led to an explosion of information about the hysiological and pathophysiological properties of these compounds. The application of this knowledge in the treatment of disease is illustrated by the development of inhibitors of the formation and actions of leukotrienes and PAF receptor antagonists. As more becomes known about synthetic pathways, receptors and receptor-effector coupling mechanisms for the lipid mediators, the more opportunities there should be for pharmacological intervention. This volume provides an overview of lipid mediators from synthesis to inhibition. It addresses the immune system and its diseases from a pharmacological viewpoint and combines clinical aspects with basic science.
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Product details

  • Hardback | 400 pages
  • 196.85 x 230 x 19.05mm | 912g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0121988759
  • 9780121988753

Table of contents

Part 1 Fatty acid derived mediators: metabolism of arachidonic acid - an overview, A.L. Willis and D.L. Smith; measurement of fatty acids and their metabolites, G. Taylor and R. Wellings; biological properties of cyclo-oxygenase products, J.R. Vane and R. Botting; other essential fatty acids, their metabolites and cell-cell interactions, M.R. Buchanan and S.R. Brister; inhibitors of fatty acid derived mediators, D.W. Hay and D.E. Griswold. Part 2 Platelet activating factor: biosynthesis and catabolism of platelet activating factor, F. Snyder; cellular sources of platelet activating factor and relating lipids, D.L. Bratton, K.L. Clay and P.M. Henson; biological properties of platelet activating factor, A.G. Stewart; platelet activating factor receptors and receptor antagonists, S.B. Hwang.
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