The Laboratory Mouse

The Laboratory Mouse

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Description

Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimer's, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.

One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.
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Product details

  • Hardback | 656 pages
  • 210 x 280 x 45mm | 2,249.85g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Approx. 550 illustrations
  • 0123364256
  • 9780123364258
  • 1,762,495

Review quote

"...a good reference on a broad range of mouse-related topics. ...the book is recommended for pathologists working in genomics research and for departmental-level libraries."
- Dr. C. B. Clifford, Charles River Laboratories for JOURNAL OF VETERINARY PATHOLOGY (2005)

"...it would be hard to find one that provides so much current and research-relevant information in one place."
- Lauretta W. Gerrity, University of Alabama at Birmingham in AMERICAN JOURNAL OF ROENTGENOLOGY

"...well written and offers interesting background information for anyone in this field." (Neuromuscular Disorders, 2005)

"...easy to navigate and highly informative..."(Animal Lab News, June 2005)

"This well-researched text with numerous tables and photographs will be used for many years to come." (Contemporary Topics, 2005)
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Table of contents

History, Development and Genetics of the Mouse as a Laboratory Model
Origin of the Laboratory Mouse and Related
Historical Foundations
Strain, Stock and Mutants
Mouse Genomics
Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis
The Mouse as an Animal Model for Human Diseases
The Mouse in Preclinical Safety Studies
Anatomy and Developmental Biology
Gross Anatomy
Normative Histology of Organs
Imaging
Introduction to Early Mouse Development
Pathophysiology (including non-infectious diseases)
Skin and Adnexes of the Laboratory Mouse
Cardiovascular System
Respiratory Tract
Gastrointestinal System and Metabolism
Inbred Mouse Models for Autoimmune Disease
Hematology of the Mouse
The Social Behaviour of Mice and its Sensory Control
Neuroendocrine - Immune Network in Stress
Circadian Rhythms of the Mouse
Gerontology
Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stock of Laboratory Mice
Infectious Agents and Diseases
Viral Infections
Animal Husbandry and Production
Housing and Maintenance
Gnotobiology and Breeding Techniques
Assisted Reproduction and Cryopreservation
Health Monitoring
Nutrition of Laboratory Mice
Procedures
Legal Regulations for the Protection of Animals Used for Scientific Experiments
Necropsy Methods
Handling and Restraint
Routes of Administration
Collection of Body Fluids
Anaesthesia, Analgesia and Euthanasia
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About Hans J. Hedrich

Edited by Hans Hedrich
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Review Text

"...well written and offers interesting background information for anyone in this field." (Neuromuscular Disorders, 2005) "...well written and offers interesting background information for anyone in this field." (Neuromuscular Disorders, 2005)
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