Klotho: Volume 101
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Klotho: Volume 101

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Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a single molecule or on a disease that is related to vitamins or hormones that are interpreted broadly so that related substances, such as transmitters, cytokines, growth factors, and others can be reviewed.
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Product details

  • Hardback | 352 pages
  • 152 x 229 x 22.86mm | 750g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0128048190
  • 9780128048191

Table of contents

Klotho-Related Protein KLrP: Structure and Functions
Yasuhiro Hayashi and Makoto Ito
The FGF21 Receptor Signaling Complex: KLOTHOï ¢, FGFR1c and Other Regulatory Interactions
Dawn M. Kilkenny and Jonathan V. Rocheleau
Klotho-Dependent Cellular Transport Regulation
Mentor Sopjani and Miribane Dermaku-Sopjani
Klotho and the Growth Hormone/Insulin-like Growth Factor 1 Axis: Novel Insights Into Complex Interactions
Tami Rubinek and Dalit Modan-Moses
Klotho Prevents Translocation of NFκB
Paula Buendia, Rafael Ramirez, Pedro Aljama and Julia Carracedo
The FGF23/KLOTHO Regulatory Network and its Roles in Human Disorders
Saori Kinoshita and Masanobu Kawai
MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity
Ting Fu and Jongsook Kim Kemper
The Role of Alpha-Klotho as a Universal Tumor Suppressor
Tami Rubinek and Ido Wolf
Klotho is a Neuroprotective and Cognition-Enhancing Protein
Carmela R. Abraham, Patrick C. Mullen, Tracey Tucker Zhou, Cidi Chen and Ella Zeldich
Function and Change with Aging of α-Klotho in the Kidney
Keiko Akasaka-Manya, Hiroshi Manya and Tamao Endo
αKlotho and Chronic Kidney Disease
Javier A. Neyra and Ming Chang Hu
Deficiency of Soluble α-Klotho as an Independent Cause of Uremic Cardiomyopathy
Jian Xie, Yueh-Lin Wu and Chou-Long Huang
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About Gerald Litwack

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote "Human Biochemistry and Disease" a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, "One-Eighty".
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