The Kinin System

The Kinin System

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Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities.
From the prepublication reviews:
"A delicious masterpiece."
--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.
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Product details

  • Hardback | 349 pages
  • 196.6 x 261.4 x 21.6mm | 930.6g
  • Academic Press Inc
  • San Diego, United States
  • English
  • b&w illustrations
  • 0122493400
  • 9780122493409

Table of contents

Discovery of Bradykinin and the Kallikrein-Kinin System. The Pharmacology and Immunopharmacology of Kinin Receptors. Molecular Pharmacology of the Kinin Receptors. Kininogens: Gene Expression, Regulation, Cell Surface Presentation. The Molecular Biology of the Kallikreins and Roles in Inflammation. Immunological Probes for the Bradykinin B2 Receptor: An Immunological Toolbox. Metabolism of Bradykinin By Peptidases in Health and Disease. Kinin B1 Receptor Induction and Inflammation. Kinins and Pain. The Kallikrein-Kinin System in Sepsis Syndrome. The Kinin System and Neutrophils. Putative Roles of Bradykinin and the Kinin System in Pancreatitis. The Role of the Kallikrein-Kinin System in Inflammation-Induced Bone Metabolism. Bradykinin as an Inflammatory Mediator in the Urinary Tract. The Kallikrein-Kinin System in Asthma and Acute Respiratory Distress Syndrome. Bradykinin Formation in Allergic Disease and Hereditary Angioedema. The Role of Kinins in Nasal Airway Function. Bradykinin as a Growth Factor. The Role of Bradykin in the Cardiac Effects of ACE Inhibitors and Myocardial Ischemia.
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