The Journal of Medical Research Volume 6

The Journal of Medical Research Volume 6

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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1901 edition. Excerpt: ...cells in the blood sinuses of the spleen is increased in number and many of them are carried to the liver, where, as careful study of very early lesions shows, they give rise to.necroses by blocking up the very narrow capillaries. However, if this line of reasoning is true for toxic substances, the same claim can be made for mechanical and electrical irritation of the spleen. For example, in the liver from one of the guinea-pigs massaged for five minutes and killed at the end of two and three-quarters hours, besides small and early but definite necroses, in certain areas numerous single liver cells and small groups of them were surrounded by phagocytic, usually pigmented, cells and were undergoing necrosis (Plate XVII., Fig. 4). It is possible of course that the animal was killed at a time when the necroses were forming under what might be considered normal conditions, and that they were not due to the mechanical setting free of the phagocytic endothelial cells in the spleen, but such a coincidence seems hardly probable. One other conclusion seems perfectly justifiable, namely, that the focal necroses of the liver in the guinea-pig, whatever the exciting cause, are due to occlusion of the capillaries partly by phagocytic and pigmented endothelial cells brought to the liver from the spleen by the portal circulation, partly to fibrin thrombi which have formed around necrotic cells. The cells around which the fibrin forms are chiefly the phagocytic cells from the spleen, but it is possible that endothelial cells of the liver capillaries or liver cells themselves may occasionally prove the starting point. The focal necroses must be regarded as miliary infarctions, due in one class of cases to cell emboli, in the other to capillary more

Product details

  • Paperback | 188 pages
  • 189 x 246 x 10mm | 345g
  • United States
  • English
  • black & white illustrations
  • 1236668316
  • 9781236668318