Ions in the Brain

Ions in the Brain : Normal Function, Seizures, and Stroke

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Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effected by the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure models, the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases.
The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.
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Product details

  • Hardback | 470 pages
  • 162.56 x 238.76 x 33.02mm | 839.14g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 8 halftones, numerous line figures
  • 0195151712
  • 9780195151718
  • 2,097,338

Review quote

. . . it has a pleasing consistency of style . . . this is an excellent book which is a must read for all interested in the fields covered. While not claiming to tell us how the brain works, Somjen sticks with the facts and describes in exquisite detail what happens when the brain malfunctions, which is surely how successful strategies for combating devastating neurological conditions will ultimately be devised. A worthy testament to an exemplary scientific career. * Physiology News, No 56 * Dr. Somjen has succeeded in producing a text that spans the divide between laboratory neurophysiology and clinical experience . . . Well written and readable . . . an excellent resource. * Archives of Neurology * An excellent overview of the different types of interactions involving ions in the brain . . . highly recommended to the researcher or clinician . . . * Clinical Neurophysiology * . . . a major contribution to our current knowledge of ions in physiological and pathological states of the brain . . . well written, with many informative subheadings, graphs, and figures. It will be of interest to neuroscientists, neurobiologists, neurophysiologists, clinicians, and their trainees. . . * European Journal of Neurology *
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Table of contents

PART I: IONS AND WATER IN THE BRAIN ; 1. The blood-brain barrier ; 2. The regulation of brain ions ; 3. Osmotic stress and the brain ; 4. The influence of ion concentrations on neuron function ; PART II: CEREBRAL SEIZURES ; 5. A primer of epileptiform seizures ; 6. Experimental seizures ; 7. Electrophysiology of seizures ; 8. Ions and seizures ; 9. Solving seizure mechanisms by simulations ; 10. Seizures, channels, genes ; 11. Mechanisms of action of antiepileptic drugs ; PART III: SPREADING DEPRESSION OF LEAO ; 12. Introduction to spreading depression: Extracellular electric signs ; 13. Ion fluxes during spreading depression ; 14. Membrane potential and input resistance during spreading depression ; 15. The mechanism of spreading depression ; 16. Solving the puzzle of spreading depression by computer simulation ; PART IV: PATHOLOGICAL BIOPHYSICS OF CEREBRAL HYPOXIA AND STROKE ; 17. Hypoxia, asphyxia and ischemia ; 18. Mechanism of early, reversible hypoxic synaptic failure ; 19. Irreversible hypoxic (ischemic) neuron injury
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