International Review of Experimental Pathology: Cytokine-induced Pathology v. 34B
This two-volume set is a comprehensive review of the "in vivo" effects in experimental animals induced by several members of the cytokine family. The volumes explain the pharmacological and toxico-pathological effect of such hematopoietic growth factors as colony stimulating factor, the novel factors IL-11 and stem cell factors. Then it summarizes the broad spectrum of activity of several immunostimulatory assays (interleukins IL-1-IL-9) in conventional toxicological assays as well as results from transgenic models. The set also features the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g and TGF-beta) competently reviewed by experts in the field. The set reviews the structure and distribution of the membrane receptors for these growth factors. It addresses the role of various cytokines in disease processes (malaria, sepsis, and meningitis). Volumes 34A and 34B also cover the clinical experience with two growth factors (interferons and GM-CSF), which clearly show that the preclinical data were predictive and valuable for the clinician. Each volume of "International Review of Experimental Pathology" contains an index, and each chapter includes references.
- Hardback | 208 pages
- 158 x 235mm | 513g
- 01 Apr 1993
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- chapter references, index
Table of contents
Part 1 Pathology induced by inflammatory cytokines: introduction, B. Ryffel; pathophysiologic alterations induced by tumour necrosis factor, D.F. Remick and S.L. Kunkel; "in vitro" and "in vivo" activity and pathophysiology of human interleukin-8 and related peptides, R. Zwahlen, et al; pathology of recombinant human transforming growth factor-B1 (rhTGF-B1) in rats and rabbits, T.G. Terrell, et al; pathology of recombinant murine interferon-g in mice and recombinant human interferon-g in cynomolgus monkeys, T.G. Terrell and J.D. Green. Part 2 Cytokine receptors: introduction, B. Ryffel; pharmacokinetic parameters and biodistribution of soluble cytokine receptors, C.A. Jacobs, et al; immunomodulation with soluble IFNG receptor - preliminary study, L. Ozmen, et al; TNF receptors distribution in human tissues, B. Ryffel, et al. Part 3 Role of cytokines in disease: tumour necrosis factor/cachectin (TNF) as an effector of T-cell depedendent immunopathology, D.E. Grau, et al; cytokines involved in pulmonary fibrosis, P.F. Piquet; immune-mediated injury in bacterial meningitis, K. Frei, et al; clinical experiences with alpha- and gamma- interferons, G.G. Steinmann, et al; clinical experience with escherichia coli rhGM-CSF, A.C. Stern and T.C. Jones.