International Review of Experimental Pathology: Cytokine-induced Pathology v. 34A
This two-volume set is a comprehensive review of the "in vivo" effects in experimental animals induced by several members of the cytokine family. The volumes explain the pharmacological and toxico-pathological effect of such hematopoietic growth factors as colony stimulating factor, the novel factors IL-11 and stem cell factors. Then it summarizes the broad spectrum of activity of several immunostimulatory assays (interleukins IL-1-IL-9) in conventional toxicological assays as well as results from transgenic models. The set also features the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g, and TGF-beta) competently reviewed by experts in the field. The set reviews the structure and distribution of the membrane receptors for these growth factors. It addresses the role of various cytokines in disease processes (malaria, sepsis and meningitis). Volumes 34A and 34B also cover the clinical experience with two growth factors (interferons and GM-CSF), which clearly show that the preclinical data were predictive and valuable for the clinician. Each volume of "International Review of Experimental Pathology" contains an index, and each chapter includes references.
- Hardback | 252 pages
- 157 x 237 x 19.05mm | 540g
- 01 Apr 1993
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- chapter references
Table of contents
Part 1 Pathology induced by interleukins: comparative toxicity and pathology associated with administration of recombinant rHuIL-1a to animals, T.D.Anderson, et al; pathogenesis of toxicity with human-derived interleukin-2 in experimental animals, Y. Harada and I. Yahara; comparative toxicity and pathology associated with administration of recombinant IL-2 to animals, T.J. Hayes; toxicity of recombinant human interleukin-4 in cynomolgus monkeys, T.A. Barbolt, et al; pathology induced by interleukin-6, B. Ryffel, et al; interleukin 6 (IL-6) in myeloma/plasmacytoma, S. Suematsu, et al; interleukin-9, J.-C. Renauld, et al. Part 2 Pathology induced by hematopoietic growth factors: comparative toxicity of escherichia coli and yeast rhu IL-3 cynmolgus and rhesus monkeys, G. Reiner, et al; preclinical safety assessment of recombinant human GM-CSF in rhesus monkeys, R.L. Robison and L.A. Meyers; granulocyte colony stimulating factor - animal studies for risk assessment, P. Keller; clinical and histopathological effects on M-CSF in laboratory animals, C.W. Johnson, et al; clinical and histopathological effects on M-CSF in laboratory animals, C.W. Johnson, et al; review of a novel hematopoietic cytokine, interleukin II, V.F.J. Quesniaux, et al; hematologic effects of stem cell factor alone and in combination with G-CSF and GM-CSF "in vivo" and "in vitro" in rodents.