Preface: Insulin Action; A.K. Srivastava, B.I. Posner. 1. The IRS-Signaling System: A Network of Docking Proteins that Mediate Insulin Action; M.F. White. 2. Role of Binding Proteins to IRS-1 in Insulin Action; W. Ogawa, et al. 3. Insulin Regulation of the Ras Activation/Inactivation Cycle; B.P. Ceresa, J.E. Pessin. 4. Insulin Signal Transduction Through Protein Kinase Cascades; J. Avruch. 5. Protein Phosphatase-1 and Insulin Action; L. Ragolia, N. Begum. 6. Insulin Receptor Internalization and Signaling; G.M. Di Guglielmo, et al. 7. Spatial Determinants of Specificity in Insulin Action; C.C. Mastick, et al. 8. Binding of SH2 Containing Proteins to the Insulin Receptor: A New Way for Modulating Insulin Signaling; F. Liu, R.A. Roth. 9. Insulin Receptor-Associated Protein Tyrosine Phosphatase(s): Role in Insulin Action; P.G. Drake, B.I. Posner. 10. Regulation of the Insulin Signalling Pathway by Cellular Protein-Tyrosine Phosphatases; B.J. Goldstein, et al. 11. Protein Tyrosine Phosphatase-1B Acts as a Negative Regulator of Insulin Signal Transduction; J.C.H. Byon, et al. 12. Multifunctional Actions of Vanadium Compounds on Insulin Signaling Pathways: Evidence for Preferential Enhancement of Metabolic Versus Mitogenic Effects; I.G. Fantus, E. Tsiani. 13. Regulation of the Na+/K+-ATPase by Insulin: Why and How? G. Sweeney, A. Klip. 14. Potential Mechanisms Involved in the Regulation of Glycogen Synthesis by Insulin; A.K. Srivastava, S.K. Pandey. 15. Metabolic and Therapeutic Lessons from Genetic Manipulation of GLUT4; M.J. Charron, E.B. Katz. 16. Insulin Action in Skeletal Muscle from Patients with NIDDM; J.R. Zierath, et al. 17. Genetic Manipulation of Insulin Action and -Cell Function in Mice; B. Lamothe, et al. 18. TNF- and Insulin Resistance: Summary and Future Prospects; P. Peraldi, B. Spiegelman. 19. Membrane Glycoprotein PC-1 and Insulin Resistance; I.D. Goldfine, et al. 20. Insulin Action on Protein Phosphatase-1 Activation is Enhanced by the Antidiabetic Agent Pioglitazone in Cultured Diabetic Hepatocytes; S. Pugazhenthi, R.L. Khandelwal. Index.