Inhibitors of the Ras Superfamily G-proteins, Part A: Volume 33

Inhibitors of the Ras Superfamily G-proteins, Part A: Volume 33

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This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.
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Product details

  • Hardback | 364 pages
  • 154.94 x 231.14 x 22.86mm | 725.74g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 0124167497
  • 9780124167490

Table of contents

The Ras superfamily G-proteins
Fuyuhiko Tamanoi
NMR Study to Identify a Ligand-Binding Pocket in Ras
Till Maurer and Weiru Wang
The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
Christian W. Johnson and Carla Mattos
State 1(T) Inhibitors of Activated Ras
Hans Robert Kalbitzer and Michael Spoerner
Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface
Alessandro Di Domizio and Francesco Peri
Development of EHop-016, a Small Molecule Inhibitor of Rac
Suranganie Dharmawardhane
Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors
Susanne Schmidt and Anne Debant
Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways
Anne Blangy and Philippe Fort
Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
Dominico Vigil and Channing J. Der
A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis
Inhibitors of K-Ras Plasma Membrane Localization
Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock
Ras Chaperons: New Targets for Cancer and Immunotherapy
Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor
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About Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.
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