Inhibitors of the Ras Superfamily G-proteins, Part B: Volume 34

Inhibitors of the Ras Superfamily G-proteins, Part B: Volume 34

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Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.
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Product details

  • Hardback | 280 pages
  • 154.94 x 231.14 x 17.78mm | 521.63g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 0124201466
  • 9780124201460

Table of contents

Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras*GTP-Effector Interaction
Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
An Orthosteric Inhibitor of the RAS-SOS Interaction
Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
Conformation-Specific Inhibitors of Raf kinases
Xiaolun Wang and Kristin Schleicher
Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers
Leanna Gentry, Ahmed A. Samatar and Channing J. Der
Inhibiting the RAS - PI3K Pathway in Cancer Therapy
Clare Sheridan and Julian Downward
The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers
Jonathan M. Cooper, Brian O. Bodemann and Michael A. White
p21-Activated Kinase Inhibitors
Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions
Fuyuhiko Tamanoi and Jie Lu
Synthetic Lethal Genetic Screens in Ras Mutant Cancers
Bing Yu and Ji Luo
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About Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.
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