Inflammatory Disorders of the Nervous System
13%
off

Inflammatory Disorders of the Nervous System : Pathogenesis, Immunology, and Clinical Management

Free delivery worldwide

Available. Dispatched from the UK in 3 business days
When will my order arrive?

Description

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
show more

Product details

  • Paperback | 362 pages
  • 178.05 x 254 x 21.59mm | 834.61g
  • Totowa, NJ, United States
  • English
  • Softcover reprint of hardcover 1st ed. 2005
  • XIV, 362 p.
  • 1617375608
  • 9781617375606

Back cover copy

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders.
Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide.
show more

Table of contents

Endothelial Cell-Leukocyte Interactions During CNS Inflammation
J. Steven Alexander and Alireza Minagar

Multiple Sclerosis: A Disease of Miscommunication Between the Immune and Central Nervous Systems?
Monica J. Carson, Crystal S. Anglen, and Corinne Ploix

Cytokines and Brain: Health and Disease
Tammy Kielian and Paul D. Drew

Chemokines and Central Nervous System Disorders
William J. Karpus

Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders
Wenche Jy, Lawrence L. Horstman, Joaquin J. Jimenez, Alireza Minagar, and Yeon S. Ahn

Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Clinical Management
William A. Sheremata

Neuroprotective Effects of Interferon-b in Multiple Sclerosis
Fabrizio Giuliani, Rana Zabad, and V. Wee Yong

Acute Disseminated Encephalomyelitis
Sean J. Pittock and Dean M. Wingerchuk

Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis
Staley A. Brod

Neuromyelitis Optica
Dean M. Wingerchuk

Transverse Myelitis: Clinical Manifestations, Pathogenesis, and Management
Chitra Krishnan, Adam I. Kaplin, Deepa M. Deshpande, Carlos A. Pardo, and Douglas A. Kerr

Optic Neuritis: Pathogenesis, Immunology, Diagnosis, and Clinical Management
Robert Zivadinov and Rohit Bakshi

Central Nervous System Vasculitis: Pathogenesis, Immunology, and Clinical Management
Shariq Mumtaz, Marjorie R. Fowler, Eduardo Gonzales-Toledo, and Roger E. Kelley

Neurosarcoidosis: Pathogenesis, Immunology, and Clinical Management
Dakshinamurty Gullapalli and Lawrence H. Phillips, II

Neuropsychiatric SLE: Pathogenesis, Immunology, and Clinical Management
Deborah Aleman-Hoey and Robin L. Brey

Gene Expression in HIV-Associated Dementia
Paul Shapshak, Alireza Minagar, Elda M. Duran, Fabiana Ziegler, Wade Davis, Raman Seth, and Toni Kazic

Human T-Lymphotropic Virus-Associated Neurological Disorders: Pathogenesis, Immunology, and Clinical Management
Michael D. Lairmore, Bindhu Michael, Lee Silverman, and Amrithraj Nair

West Nile Virus Infection of the Nervous System: Pathogenesis, Immunology, and Clinical Management
Douglas J. Lanska

Index
show more

Review Text

From the reviews:

"The objective of this book is to provide the readers with a highly detailed review of the basic principles of neuroinflammation and extensive updates of the latest findings on common neuroinflammatory disorders. ... The treatment principles of the different inflammatory disorders are very well covered and up-to-date. This book can be of interest for the institutional library in order for doctors to look up specific details and treatment principles, and to enter deeply into neuroimmunological basics." (Orvar Eeg-Olofsson, European Journal of Paediatric Neurology, Vol. 11, June, 2007)
show more

Review quote

From the reviews:





"The objective of this book is to provide the readers with a highly detailed review of the basic principles of neuroinflammation and extensive updates of the latest findings on common neuroinflammatory disorders. ... The treatment principles of the different inflammatory disorders are very well covered and up-to-date. This book can be of interest for the institutional library in order for doctors to look up specific details and treatment principles, and to enter deeply into neuroimmunological basics." (Orvar Eeg-Olofsson, European Journal of Paediatric Neurology, Vol. 11, June, 2007)
show more