The Implicit Genome

The Implicit Genome

3 (2 ratings by Goodreads)
Edited by 

Free delivery worldwide

Available. Dispatched from the UK in 3 business days
When will my order arrive?

Description

For over half a century, we have been in the thrall of the double-helicaln structure of DNA, which, in an instant, revealed that information can be transferred between generations by a simple rule, A pairs with T, G pairs with C. In its beautiful simplicity, this structure, along with the table of codons worked out in the following decade, had entranced us into believing that we can fully understand the information content of a DNA sequence, simply by treating it as text that is read in a linear fashion. While we have learned much based on this assumption, there is much we have missed. Far from a passive tape running through a reader, genomes contain information that appears in new forms which create regions with distinct behavior. Some are "gene rich", some mobile, some full of repeats and duplications, some sticking together across long evolutionary distances, some readily breaking apart in tumor cells. Even protein-coding regions can carry additional information, taking advantage of the flexible coding options provided by the degeneracy of the genetic code. The chapters in this volume touch on one or more of three interconnected themes: information can be implied, rather than explicit, in a genome; information can lead to focused and/or regulated changes in nucleotide sequences; information that affects the probability of distinct classes of mutation has implications for evolutionary theory.show more

Product details

  • Paperback | 400 pages
  • 154.9 x 231.1 x 20.3mm | 381.02g
  • Oxford University Press Inc
  • New York, United States
  • English
  • New.
  • 80 line drawings
  • 019517271X
  • 9780195172713
  • 2,005,676

Review quote

A timely edited volume examining what information can be implied in a genome, thereby "highlighting some of the major challenges in contemporary genomics"- Dan Hartl, Harvard Universityshow more

About Lynn Helena Caporale

Dr. Lynn Helena Caporale received her Ph.D. in Molecular Biology from the University of California at Berkeley and is the author of Darwin and the Genome. She is the Associate Director for Comparative Genomics at the Judith P. Sulzberger Genome Center at Columbia University.show more

Rating details

2 ratings
3 out of 5 stars
5 0% (0)
4 0% (0)
3 100% (2)
2 0% (0)
1 0% (0)
Book ratings by Goodreads
Goodreads is the world's largest site for readers with over 50 million reviews. We're featuring millions of their reader ratings on our book pages to help you find your new favourite book. Close X