Immunotherapy of Cancer
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Immunotherapy of Cancer

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Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
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Product details

  • Hardback | 516 pages
  • 184 x 256 x 30mm | 1,138.53g
  • Totowa, NJ, United States
  • English
  • 2006 ed.
  • 52 Illustrations, black and white; XII, 516 p. 52 illus.
  • 1588295648
  • 9781588295644

Back cover copy

Major scientific advances in molecular and clinical immunology have produced tremendous growth in our understanding of how cancer is recognized by the immune system, as well as in our ability to control and modulate that recognition. In Immunotherapy of Cancer, expert bench and clinical scientists join forces to concurrently review both the state of the art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T-cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunological monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Comprehensive and cutting-edge, Immunotherapy of Cancer offers immunologists an exhaustive and authoritative survey of cancer immunotherapy, as well as providing a springboard for applying the most important findings in tumor immunology to any basic laboratory program or clinical oncology practice.
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Table of contents

Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic Approaches
OEzlem Tureci, Thorsten Klamp, Michael Koslowski, Sebastian Kreiter, and Ugur Sahin

Current Strategies for the Identification of Immunogenic Epitopes of Tumor Antigens
Ludmila Muller, Stephanie McArdle, Evelyna Derhovanessian, Thomas Flad, Ashley Knights, Robert Rees, and Graham Pawelec

Current and Future Role of Natural-Killer Cells in Cancer Immunotherapy
Lisa M. Harlan and Julie Y. Djeu

The Role of Immune Monitoring in Evaluating Cancer Immunotherapy
Holden T. Maecker

Statistical Analysis of Immune Response Assays in Cancer Immunotherapy Trials
Susan Groshen

DNA Vaccines for Cancer Immunotherapy
Heesun Kwak and Howard L. Kaufman

Dendritic Cells
Weiping Zou and Tyler J. Curiel

Different Approaches to Dendritic Cell-Based Cancer Immunotherapy
Noweeda Mirza and Dmitry Gabrilovich

Anti-Idiotype Antibody Vaccines for the Immunotherapy of Cancer
Malaya Bhattacharya-Chatterjee, Nitin Rohatgi, Sunil K. Chatterjee, Asim Saha, Rakesh Shukla, and Kenneth A. Foon

Autologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer Therapeutics
Jie Dai and Zihai Li

Tumor-Reactive T-Cells for Adoptive Immunotherapy
Helga Bernhard, Julia Neudorfer, Kerstin Gebhard, Heinke Conrad, Dirk H. Busch, and Christian Peschel

T-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical Significance
Peter A. Cohen, Mohamed Awad, and Suyu Shu

Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells
Jeffrey J. Roszkowski and Michael I. Nishimura

Harnessing the Potential of Graft-vs-Tumor
Nancy M. Hardy and Michael R. Bishop

Tumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome ofImmunotherapy of Malignant Disease
Michael Campoli and Soldano Ferrone

The Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for Immunotherapy
George Coukos and Jose-Ramon Conejo-Garcia

Manipulation of Lymphocyte Homeostasis for Enhancing Antitumor Immunity
Eduardo Davila and Esteban Celis

Fast-Lane Evolution in the Tumor Microenvironment
Gabriella Marincola and Francesco M. Marincola

Manipulating Immunological Checkpoints to Maximize Antitumor Immunity
Leisha A. Emens, R. Todd Reilly, and Elizabeth M. Jaffee

Interleukin-2 as Cancer Therapy
Joseph I. Clark and Kim A. Margolin

Biological and Clinical Properties of the Type 1 Interferons
Douglas W. Leaman, Shaun Rosebeck, and Ernest C. Borden

Promising g-Chain Cytokines for Cancer Immunotherapy: Interleukins-7, -15, and -21 as Vaccine Adjuvants, Growth Factors and Immunorestoratives
Terry J. Fry and Crystal L. Mackall

The Therapeutic Use of Natural-Killer Cells in Hematological Malignancies
Sherif S. Farag and Michael A. Caligiuri

Antibody Therapy for Solid Tumors
Cristina I. Truica, Dorinda Rouch, and Carlos L. Arteaga

Antibody Therapy for Non-Hodgkin's Lymphoma
Stephen M. Ansell and Thomas E. Witzig

Approaches to In Vivo Imaging of Cancer Immunotherapy
George A. Vielhauer, Bond Almand, Mary L. Disis, David A. Mankoff, and Keith L. Knutson

Design Issues for Early-Stage Clinical Trials for Cancer Vaccines
Gina R. Petroni

Monoclonal Antibody Therapy of Cancer
Hossein Borghaei, Matthew K. Robinson, and Louis M. Weiner

Index
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Review Text

From the reviews:

"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. ... The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers ... ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)
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Review quote

From the reviews:





"Immunotherapy of Cancer provides in 28 chapters a comprehensive overview of experimental and clinical achievements in tumor immunology. Each chapter is designed to give the reader the scientific basis behind the discussed therapy and outline basic theory, as well as practical treatment applications. ... The book belongs to the successful series of publications Cancer Drug Discovery and Development from Humana Press. It will be of interest to clinicians and to laboratory cancer researchers ... ." (Cestmir Altaner, Neoplasma, Vol. 54 (2), March, 2007)
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