Immunoregulation and Foetal Survival

Immunoregulation and Foetal Survival

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Based on the second Banff Conference on reproductive immunology, this book offers a comprehensive view of immunoregulation and genetic interactions at the maternal-foetal interface, including both animal models and human experimental or clinical research. It focuses on the central issue in this field: the immune mechanisms involved in the survival of a foetus separated from the maternal circulation by a thin, semipermeable wall of cells - the trophoblast, a part of the placenta. To the immunologist, the placenta poses the problem that genetically different tissue is intimately exposed to maternal immunocompetent cells, but does not cause an effective immune reaction. To the geneticist and developmental biologist, it raises a variety of questions about the regulation of development. These research concerns have their counterparts in the clinical fields of obstetrics (chronic spontaneous abortion and intrauterine growth retardation), paediatrics (birth defects, failure to thrive, and chronic graft-versus-host disease), oncology (trophoblast growth regulation, teratocarcinoma, and choriocarcinoma), and pathology (structural and functional bases for these defects).
Progress in this field has led to clinical trials of immunological manipulation for promoting human foetal survival. Readership: Immunologists; reproductive and developmental biologists; human geneticists; clinical researchers in obstetrics and gynaecology.
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Product details

  • Hardback | 350 pages
  • 157.48 x 236.22 x 25.4mm | 680.39g
  • New York, United States
  • English
  • 59 figures, tables
  • 0195039890
  • 9780195039894

Table of contents

Thomas J Gill III and Thomas G Wegmann: Immune recognition, genetic regulation, and the life of the fetus; PART I: MATERNAL SYSTEMATIC IMMUNITY; W D Billington and M Davies: Maternal antibody to placental syncytiotrophoblast during pregnancy; R N Smith, A Amsden, O Sudilovsky, N Coleman, and R Margolies: The alloantibody response in the allogeneically pregnant rat; Michael G Steele and Gerrie A Leslie : IgD and the maternal-fetal interface; Judith R Head: Lymphoid components in the rodent uterus; PART II: DECIDUA; David A Clark, Angela Chaput, Renata M Slapsys, Joyce Brierley, Salim Daya and Randall Allardyce: Suppressor cells in the uterus; P K Lala, M Kearns, and R S Parhar: Immunology of the decidual tissue; R F Searle, J M Elcock, and C J Matthews: Antigen presentation by mouse decidua and placenta; Judith N Bulmer, Peter M Johnson, Sandra Peel and the late David Bulmer: Leukocytic populations in human decidua and endometrium; PART III: TROPHOBLAST; Thomas J Gill III, Trevor A Macpherson, H N Ho, Heinz W Kunz, Andrea Cortese Hassett, Kimberly S Stranick and Joseph Locker: Immunological and genetic factors affecting implantation and development in the rat and the human: A unique trophoblast antigen and genes regulating development; J Rossant and B A Croy: Properties of the trophectoderm lineage in mouse development; Toshiyuki Hamaoka, Kiichiro Itoh, Yutaka Izumi and Shiro Ono: Selective suppression of class II MHC directed responses by soluble factors; Peter M Johnson, Janet M Risk, Judith N Bulmer, Zbigniew Niewola and Ian Kimber: Antigen expression at human maternal-fetal interfaces; Y W Loke and Bridget H Butterworth: Heterogeneity of human trophoblast populations; C W G Redman, J Arenas, D Y Mason, I L Sargent and L Sutton : Maternal alloimmune recognition of the fetus in human pregnancy; PART IV: FETAL SURVIVAL; Boris Tartakovsky: Immune disruption of gestation; Gerard Chaouat, Jean-Pierre Kolb, S Chaffaux, M Riviere, I Athanassakis, D Green and Thomas G Wegmann: The placenta and the survival of the fetal allograft; P Bobe, M Stanislawski and N Kiger: Immunogenetic studies of spontaneous abortion in mice; W R Allen, Julia H Kydd, D F Antczak: Maternal immunological response to the trophoblast in xenogeneic equine pregnancy; Alan E Beer, James F Quebbeman, Yoichi Hamazaki and A E Semprini: Immunotherapy of recurrent spontaneous abortion; James F Mowbray: A controlled trial of immunotherapy with paternal cells in recurrent spontaneous abortion; PART V: PERSPECTIVES; W B Neaves and R E Billingham: Tissue therapy revisited.
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