Immunophysiology : The Role of Cells and Cytokines in Immunity and Inflammation
This exciting new text describes how cells normally regulate immunological and inflammatory reactions, and how the immune system is intimately related to other bodily functions. The authors consider the effects of lymphokines on non-inflammatory cells and tissues, including connective tissue and the neuroendocrine system, and describe the effects of neuroendocrine and peptide growth factors produced by non-inflammatory cells and tissues on the functions of immune cells. To highlight the factors regulating immunophysiological functions, they discuss the inflammatory consequences of endotoxin, immune complexes, and complement; the interactions of immunomodulating epidermal factors and immune tissue; the modulation interactions of immunomodulating epidermal factors and immune tissue; and the modulation of immunity by cytokines. The mechanisms by which the immune system normally contends with bacterial, viral or tumor challenges are examined, with an emphasis on basic concepts and key experimental results; and the cells directly involved in host-defense processes are discussed. Wherever possible, information about in vivo and in vitro human immune responses is presented.
- Hardback | 450 pages
- 175 x 255mm | 1,078g
- 01 Feb 1990
- Oxford University Press Inc
- New York, United States
About Joost J. Oppenheim
Joost J. Oppenheim is Chief, Laboratory of Molecular Immunoregulation at the National Cancer Institute. Ethan M. Shevach is Head of the Cellular Immunology Section, Laboratory of Immunology at the National Institute of Allergy and Infectious Disease, and editor of The Journal of Immunology.
Table of contents
A.M. Moulin & A.M. Silverstein: History of immunophysiology; A.D. Anderson: Structure and organization of the lymphatic system; F.W. Ruscetti: Interleukin; W.L. Farrar et al: Transduction; R.L. Coffman et al: Interleukins and interferons acting on B lymphocytes; E.M. Shevach: Intercellular interactions in the immune response; M. Potter & S.J. Smith-Gill: Physiology of immunoglobulins; T. Borsos & E.J. Leonard: The physiologic functions of complement; J.N. Ihle: Lymphokine regulation of hematopoietic cell development; R.M. Friedman: Interferons; S.K. Durum et al: Immunophysiological role of interleukin 1; B. Beutler & A. Cerami: Cachectin (tumor necrosis factor); S.N. Vogel & M.M. Hogan: The role of cytokines and endotoxin-mediated host responses; J.D. Sipe: The acute phase response; M.W. Verghese & R. Snyderman: Role of chemotactic and inflammatory cytokines; T.S. Kupper: Role of epidermal cytokines; S.L. Brown & E. Blalock: Neuroendocrine immune interactions; L.R. Ellingsworth: Effect of growth factors on immunity and inflammation; C.W. Reynolds & J.R Ortaldo: Nature and physiology of natural effector cells; P.A. Henkart: Lymphocyte cytotoxic mechanisms; R.H. Wiltrout & L. Varesio: Activation of macrophages for cytotoxic and suppressive effector functions; D.B. Weiner et al: Role of cells and factors in immune suppression in animal models; N.K. Damle & E.G. Engleman: Role of suppressor T. cells and suppressor circuits.