Immunophysiology of the Gut
This volume integrates knowledge of physiology and the mucosal immune system by providing a systematic survey of the information available on the immunophysiology of the gut. The text features contributions from mucosal immunologists, physiologists and enteric neurophysiologists, who critically evaluate the significance of their findings. This book describes the concept of gut immunophysiology and emphasizes the association between lymphocytes (and their soluble products) and the function of the gastrointestinal tract. It presents information on how the role of nutrition effects both GI hormone release and lymphoid cytokine release, both of which influence physiologic processes. This volume also discusses key issues, such as the role of lymphokines on mucosal function, endocrine control of mucosal immune function and the effects of nutrition and malnutrition on GI function.
- Hardback | 432 pages
- 152.4 x 231.14 x 27.94mm | 612.35g
- 01 Jun 1993
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
Table of contents
Part 1 Immunophysiology of the Gut: G.A. Castro, Immunological Regulation of Epithelial Interactions - The Sub-epithelial Fibroblastic Sheath as a Paracrine Modulator of Inflammation-Induced Intestinal Secretion. E.B. Chang, Immune Regulation of Intestinal Arachidonic Acid Metabolism - Effects on Intestinal Water and Electrolyte Transport. D.G. Gall, Gastrointestinal Anaphylaxis - Effect on Gastric Intestinal Function. K.E. Barrett, Acute and Chronic Control of Colonic Chloride Secretion by Mast Cell Mediators. Part 2 Lymphokines and Mucosal Immune Function: B.K Wershil and W. Strober, Cytokines and Immune Regulation - An Overview. T.T. MacDonald, Antigen-independent and Antigen-dependent Development of Mucosal Hypersensitivity. L.F Mayer, Gamma Interferon and Class II Antigen Expression on Enterocytes. J.L. Madara, Modelling the Intestinal Crypt Abscess - A Characteristic Lesion of Acute Intestinal Inflammation. S.P. James, Role of Lymphokines in Function of Gastrointestinal Mucosal T Cells. C. Fiocchi, Cytokine Production During Inflammation. Part 3 Endocrine Effects on Mucosal Immune Function. J. Bienenstock, Neuroimmune Interactions in the Regulation of Mucosal Immunity. C.R. Wira, Sex Hormone, Glucocorticoid and Cytokine Regulation of Mucosal Immunity: Hormonal Influences on Antibody Levels and Antigen Presentation in the Female Genital Tract. J.D. Wood, Enteric Neuroimmune Interactions. M.H. Perdue, Neuroimmune Amplification and Inhibition of Mucosal Function. Part 4 Nutrition and Mucosal Host Defense: L. Hanson, Breast Milk - Role In Neonatal Host Defense. O. Koldovsky, Milk-Borne Peptide Growth Factors in Human and Bovine Milk. P. Brandtzaeg, The Serologic and Mucosal Immunologic Basis of Celiac Disease. S. Strobel, Food Allergy - Role of Mucosal Regulation and Oral Tolerance. Part 5 The Effects of Nutritional Factors and the Microenvironment on Mucosal Immune Function: R. MacDermott, Introduction. P. Ogra, Effect of Intestinal Microenvironment on Mucosal Immune Reponse to Viruses. R. Chandra, Nutritional Deficiencies and Intestinal Mucosal Immunity. S. Baker. Enteric Versus Parenteral Feeding and Mucosal Function.