Immunopharmacology of the Gastrointestinal System

Immunopharmacology of the Gastrointestinal System

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Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.
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Product details

  • Hardback | 256 pages
  • 196.1 x 260.9 x 19.8mm | 641.97g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0127328602
  • 9780127328607

Table of contents

Neuromodulation of gastrointestinal immune and inflammatory responses, A.D. Defus; immunomodulation of the gastrointestinal epithelium, M.H. Pedue and D.M. McKay; the immune modulation of intestinal motor function, S.M. Collins; modulation of neutrophil function as a mode of therapy for gastrointestinal inflammation, I.S. Sandhu and M.B. Grisham; the vascular endothelium in gastorintestinal inflammation; P. Kviety and N. Granger; modulation of mast cell function in the gastrointestinal tract, E.Y. Dissonnette and A.D. Deyfus; immunopathophysiology of the gastrointestinal tract - role of platelet-activating factor, P. Kubes; immunopharmacology of eicosanoids in the gastrointestinal tract, J.L. Wallace; nitric oxide and the gastrointestinal tract, B.J.R. White; glucocorticoids and gastrointestinal inflammation, L. Parents and K.G. Mugridge.
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