Immunopharmacology of Eosinophils

Immunopharmacology of Eosinophils

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The consequences of diseases involving the immune system such as AIDS and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases and a drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a result, this area has not gained the prominence of other new fields such as molecular pharmacology of neurophamacology and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. "The Handbook of Immunopharmacology" series is a collection of volumes on aspects of immunopharmacology. Editors have been sought for each volume who are not only active in their respective area of expertise but who also have a distinctly pharmacological bias to their research.
The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("Cell Types and Mediators"). The second covers each of the major organ systems and the diseases involving the immune systems and inflammatory responses that can affect them ("Systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("Drugs"). To enhance the usefulness of the series as a reference and teaching aid, all illustrations have been standardized. Similarly, a standardized system of abbreviations of terms has been adopted. A glossary of illustrations and of abbreviated terms is featured in each volume. The eosinphil was identified more than a century ago and at first dismissed as just another polymorphonuclear cell. Later, it was considered to play a pivotal role in countering the potentially damaging effects of mast cell degranulation via the production of neuralizing enzymes. Reappraisal followed the demonstration of toxic effects of the eosinophil's catatonic proteins.
Instead of a cell with predominantly beneficial properties, the eosinphil was seen as actively contributing to the pathogenesis of chronic inflammatory diseases such as asthma. This volume summarizes the results of the last 20 years renewed interest in the biology of the eosinophil and includes review of the progress in identifying and characterizing eosinophil-derived mediators of inflammation and cytotoxicity, defining the mechanisms responsible for eosinophil differentiation and the regulatory processes involved in eosinophil accumulation and secretion and prospects for the pharmacological control of eosinophil production and function.
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Product details

  • Hardback | 306 pages
  • 189 x 254 x 20mm | 704g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0126522707
  • 9780126522709

Table of contents

The natural of eosinophilis, C.J.F. Spry; interleukin-5 and the regulation of cosinophil production, C.J. Ganderson; lipid, peptide and cytokine mediators elaborated by eosinophils, P.F. Weller; mechanisms of cytotoxity, P. Venge; eosinophil heterogeneity, W.F. Owen; eosinophil accumulation, secretion and activation, G.M. Walsh, et al; stimulus-response coupling in eosinophils - receptors, signal trasduction and pharmacological modulation, M.A. Giembvcz and P.J. Barnes; eosinophils and parasitic diseases, A. Butterworth and K.J.I. Thorne; eoisinophil associated diseases, J.H. Butterfield and K.M. Lieferman; animal models of eosinophilia, R.M. Cook, et al; experimental techniques with eosinophils, T. Hansel and C. Walker.
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