Immunology of the Nervous System

Immunology of the Nervous System

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Neuroimmunology has come of age since 1980, shaped by advances in its parent disciplines of neuroscience and immunology. As the field has evolved, it has become clear that the general principles of immunology must be applied in a highly specialized fashion when dealing with immunological reactions in the nervous system. This book provides a comprehensive review of the field. It begins with a unique historical survey including disease-related observations, followed by an overview of immunological principles and functions. Cellular responses that occur during neuroimmunological events, with emphasis on microglia, macrophages, astrocytes, and lymphocytes, are then presented. The next and largest section of the book deals with the cellular and humoral roles of the nervous and immune systems in basicphysiological and disease processes such as antigen presentation, cytokines expression, viral infection and immunosuppression. The final section on neuroimmunology of disease covers autoimmune disorders, AIDS, cancer, and the immunological diseases of the peripheral nervous system. For neuroscientists, immunologists, and neurologists, this will be a valuable resource.
It can be used as a text in neuroimmunology courses or as a reference by basic scientists and clinicians.
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Product details

  • Hardback | 846 pages
  • 172.72 x 236.22 x 38.1mm | 1,599.98g
  • New York, United States
  • English
  • 45 halftones, 29 line drawings, bibliography
  • 0195078179
  • 9780195078176

Table of contents

PART I: HISTORY OF NEUROIMMUNOLOGY--BYRON WAXMAN, FOUNDATION FOR MICROBIOLOGY; PART II: BASIC CONCEPTS; 2. Overview of the Immune System--Emil Unanue, Washington University; 3. Immunologic Principles Related to the Nervous System in the Eye--J. Wayne Streilein and Andrew W. Taylor, Schepins Eye Research Institute; 4. Cervical Lymphatics, The Blood-Brain Barrier and the Immunoreactivity of the Brain--Helen F. Cserr and Paul M. Knopf, Brown University; PART III: IMMUNOLOGICALLY-ACTIVE CELLS; 5. Microglia and Macrophages--V. Hugh Perry and Siamon Gordon, Oxford University; 6. Astrocytes: Normal Aspects and Response to CNS Injury--Michael D. Norenberg, University of Miami; 7. Lymphocyte Trafficking in the Central Nervous System--Anne Cross and William Hickey, Washington University; 8. Innervation of Lymphoid Orans and Neurotransmitter/Lymphocyte Interactions--Denise L. Bellinger, Suzanne Y. Felton, and David L. Felten, University of Rochester; PART IV: CELLULAR AND HUMORAL IMMUNE RESPONSES IN THE NERVOUS SYSTEM; 9. Autoantigens of the Nervous System--Lou Ann Barnett and Robert S. Fujinami, University of Utah; 10. Antigen Presentation in the Nervous System--Johnathan D. Sedgwick, University of Sidney; 11. Cytokine Expression in the Nervous System--Etty N. Benveniste, University of Alabama; 12. CD4+ Effector Cells in Neuroimmune Disorders--Hartmut Wekerele, Max-Planck-Institut fur Psychiatrie; 13. Direct Cell-Mediated Responses in the Nervous System--Wendy S. Armstrong and Lois A. Lampson, Harvard Medical School; 14. Neuroendocrine-Immune Interactions--Douglas A. Weignet and J. Edwin Blalock, University of Alabama; 15. Viral Infections of the Central Nervous System--Volker ter Meullen, Institut fur Virologie und Immunobiologie; 16. Transplantation into the Central Nervous System--Macieh Poltorak and William J. Freed--NIMH Neuroscience Center; 17. Immunosuppression: CNS Effects--Robert Keane, University of Miami; 18. Immunology of the Eye--Scott W. Cousins and Richard D. Dix, University of Miami; PART V: NEUROIMMUNOLOGY OF DISEASE; 19. Autoimmune Disease of the Central Nervous System--Claude P. Genain and Stephen L. Hauser, University of California, San Francisco; 20. AIDS and the Nervous System--Lawrence S. Honig, Stanford University; 21. Tumors of the Central Nervous System--Carol J. Wilkstrand and Darrell J. Bigner, Duke Comprehensive Cancer Center; 22. Immunological Disease of the Peripheral Nervous System--Rachel George and Jack Griffin, Johns Hopkins University
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