Immunoconjugates : Antibody Conjugates in Radio-imaging and Therapy of Cancer

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The contributors to this volume represent most of the established research groups in this important new field. Together they offer a comprehensive overview of current approaches to antibody conjugates as selective agents for cancer therapy and radioimaging, covering all pertinent topics from chemical synthesis to clinical trial. The book examines in vitro targeting of substancs to cells that bear antigenic markers, experimental results with live animals, and current and potential clinical applications of immunoconjugates. Readership: immunologists; oncologists; more

Product details

  • Hardback | 318 pages
  • 158 x 236 x 20mm | 703.06g
  • Oxford University Press Inc
  • New York, United States
  • English
  • figures, tables
  • 0195042107
  • 9780195042108

Table of contents

C W Vogel: Targeting of toxins, radioisotopes, and biological response modifiers; Kenneth O Lloyd: Human tumor antigens: targets for mouse monoclonal antibodies; Edward J Wawrzynczak & Philip E Thorpe: Methods for preparing immunotoxins: effect of the linkage on activity and stability; R Jerrold Fulton, Nancy Street, Jonathan W Uhr & Ellen S Vitetta: Immunotoxins containing Ricin A and B chains; L L Houston & S Ramakrishnan: Immunotoxins made with toxins and hemitoxins other than Ricin; P Casellas & Franz K Jansen: Enhancement of A-chain immunotoxins by pharmacological agents; Vic Raso: Mediation of toxin entry into cells via naturally occurring ligand receptor sites; Richard J Youle & David M Neville Jr: Role of endocytosis and receptor recycling in ligand-toxin and antibody-toxin conjugate activity; Carl-Wilhelm Vogel: Antibody conjugates without inherent toxicity: the targeting of cobra venom factor and other biological response modifiers; Michael Sela & Esther Hurwitz: Conjugates of antibodies with cytotoxic drugs; Daniel Vallera: The use of immunotoxins in bone marrow transplantation: eradication of T cells and leukemic cells; Alton C Morgan Jr, John W Pearson & Robert K Oldham: Preclinical evaluation of immunoconjugates; David M Goldenberg, Hildegard Goldenberg & F James Primus: Cancer diagnosis and therapy with radio-labelled antibodies; Robert K Oldham: Perspectives on the use of immunotoxins in clinical medicine; Lynn E Spitler: Phase 1 clinical trials with more