Hypoxia, Metabolic Acidosis and the Circulation

Hypoxia, Metabolic Acidosis and the Circulation

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This new volume discusses the implications of recent findings on the pathophysiology, development, and treatment of hypoxic metabolic acidosis. The volume is part of the Clinical Physiology series sponsored by the American Physiological Society, and is based on a FASEB symposium. The author shows how hypoxia and metabolic acidosis affect the heart, lungs, blood vessels and other organs at the cellular level, the tissue level, and finally, at the level of the entire organ. The book then proceeds to a description of the situations in which hypoxic metabolic acidosis develops, such as during high altitude exposure, cardiac arrest, and lactic acidosis. The last few chapters give an overview of treatment. Traditional therapy has consisted largely of the intravenous administration of sodium bicarbonate. This method has come under increasing scrutiny however, and the range of problems associated with the use of sodium bicarbonate is examined fully. Alternative agents for managing hypoxic acidosis are reviewed as well. This up-to-date review of hypoxia and metabolic acidosis should be of interest to all physiologists, internists, cardiologists, chest physicians, anaesthesiologists, and intensive care specialists.show more

Product details

  • Hardback | 226 pages
  • 180.3 x 260.9 x 22.4mm | 661.87g
  • Oxford University Press Inc
  • New York, United States
  • English
  • numerous line illustrations, tables
  • 0195060628
  • 9780195060621

Table of contents

Part I: Pathophysiology of Hypoxia/Acidosis: Virend K. Somers, Allyn L. Mark, Francois Abboud: Circulatory regulation during hypoxia and hypercapnia; Julian I.E. Hoffman: Regulation of myocardial blood flow and oxygen delivery during hypoxia; John B. West: Acid-base status and blood lactate at extreme altitude; Carl S. Apstein: Effects of Ischemia, hypoxia, and acidosis on cardiac systolic and diastolic function, and glycolytic metabolism in normal and hypertrophied hearts; Part II: Clinical Manifestations of Hypoxia: R.D. Cohen: Clinical implications of the pathophysiology of lactic acidosis: The role of defects in lactate disposal; Bryan E. Marshall, Carol Marshall: Acidosis and the pulmonary circulation; Allen I. Arieff: Pathogenesis of metabolic acidosis with hypoxia; Robert M. Bersin: Effects of sodium bicarbonate on mycardial metabolism and circulatory function during hypoxia; Max Harry Weil, Fulvio Kette, Raul J. Gazmuri, Eric C. Rackow: Clinical and experimental studies on alkalinizing agents for treatment of cardiac arrest; Allen I. Arieff: Therapy of lactic acidosis: Alternatives to sodium bicarbonate.show more