Human Cholinesterases and Anticholinesterases

Human Cholinesterases and Anticholinesterases

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Molecular biological approaches have deepened our understanding of the role that cholinesterases play in regulating the action of the neurotransmitter acetylcholine, in embryonic cell development and in tumour development. This text reviews the latest molecular studies of cholinesterase expression, structure and function. "Human Cholinesterases and Anticholinesterases" is conveniently divided into three parts, each of which presents different points of view on human cholinesterase research. The first part discusses the biochemical and biological backgound on human CHEs, taking into consideration our recently acquired molecular know-how; the second displays an updated report of the molecular characterization of the human cholinesterase genes and their multi-leveled regulation; and the third part offers a cumulative discussion of the scientific, ecological and clinical implications of these findings. This volume features primary sequence information based on crystallographic data and discusses structure-function relationships from recombinant human cholinesterases, focusing on how they reveal catalytic mechanism and inhibitor interactions.
It also investigates how chromosomal mapping and newly-discovered mutations in the human cholinesterase genes may predict variable drug responses and sensitivity to organophosphorous poisons and succinylcholineapnea, In addition, it considers "in vivo" amplifications and antisense oligonucleotides. The book includes a comprehensive bibliography, in addition to a list of generic drug names.
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Product details

  • Hardback | 300 pages
  • 149.86 x 228.6 x 20.32mm | 635.03g
  • Academic Press Inc
  • San Diego, United States
  • English
  • bibliography, index
  • 0126552908
  • 9780126552904

Table of contents

Part 1: Biochemical and Biological Background Overview of Cholinesterases. Biochemically Defined Subsites and Their Roles in Hydrolyzing Activity. Anti-Cholinesterases. Cell Type and Subcellular Localisation of Cholinesterases. Molecular Polymorphism and Its Genomic Origin. Putative Biological Role(s) of Cholinesterases. Evolutionary Divergence and Conservation of Cholinesterases. Genetic Variants of Human Cholinesterases. Cholinesterases and Disease States. Part 2: Human Cholinesterase Genes and Their Expression: Molecular Cloning and Expression of Human Cholinesterase Coding Sequences. Promoter Elements and Alternative Splicing the Human ACHE Gene. Search for the Molecular Origins of BCHE Polymorphism by cDNA Screening, Deletion Mutagenesis, and Xenopus Oocyte Co-Injections. Chromosomal Localization of Human Cholinesterase Genes. The Genomic Origin of Butyrylcholinesterase Variants: Multiple Point Mutations in the BCHE Gene. Structure-Function Relationships inhuman Butyryicholinesterase Variants. Manipulations of BCHE Gene Expression Modulate Murine Megakarycytopoiesis in Vitro. In Vivo Amplification of the Human CHE Genes. Part 3: Scientific and Environmental Implications: The Human ACHE and BCHE Genes: Comparative Analysis. Expression of Recombinant ACHE and BCHE Microinjected Xenopus Oocytes. Unusual Tumor BCHEmRNA Transcripts. In Ovo Expression of Human BCHE Muteins Reveals Structure-Function Relationships. Isolation of Mutated BCHEDNA Sequences from cDNA Libraries and Their Detection in Genomic DNA. Putative Involvement of Cholinesterases in Development. Modifications in the Human CHE Genes. Pollution and Ecological Implications.
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