How to Scale-Up a Wet Granulation End Point Scientifically
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How to Scale-Up a Wet Granulation End Point Scientifically

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Description

How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point.

Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process.
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Product details

  • Paperback | 88 pages
  • 152 x 229 x 7.62mm | 160g
  • Academic Press Inc
  • San Diego, United States
  • English
  • black & white illustrations
  • 0128035226
  • 9780128035221

Table of contents

1. Scale-Up Basics
2. Dimensional Analysis, Principle of Similitude, Dimensionless Numbers, Comparison of attainable Froude Numbers
3. Scientific scale-up procedure
4. Case Studies
5. Practical Considerations for End-Point Scale-Up
6. List of Symbols and Dimensions, Literature Reference
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About Michael Levin

Michael Levin has over 30 years of experience in the field of pharmaceutical scale-up, instrumentation and process optimization. He has edited a "Pharmaceutical Process Scale-Up" book, and has contributed chapters on "Tablet Press Instrumentation" and "Wet Granulation: End-Point Determination and Scale-Up" in the Encyclopedia of Pharmaceutical Technology. Michael holds a M.Sc. degree in History and Philosophy of Science from Hebrew University of Jerusalem and Ph.D. in BioMathematics (1980) from University of Washington in Seattle. His Post Doctorate studies were at University of Houston, Department of Mechanical Engineering. He participated in numerous wet and dry granulation and tableting projects in major pharmaceutical companies as a provider of process analytical instrumentation, conducted many seminars, performed numerous consulting services and wrote expert reports to clients in the pharmaceutical industry.
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