Foreword; J.D. Finkelstein. Editor's Historical Preface. List of Contributors. Note on Nomenclature. Dedication. 1. Introduction; I. Graham, K. Robinson. 2. Historical Aspects of the Relationship Between Homocysteine and Vascular Disease; D.E.L. Wilcken. 3. Biochemistry and Metabolism; D.W. Jacobsen. 4. Reference Ranges for Homocysteine Concentrations; J.B. Ubbink, R. Delport. 5. Determinants of Plasma Homocysteine; P.M. Ueland, et al. 6. Epidemiology of Homocysteine Levels and Relation to Vitamins; P.W.F. Wilson, P.F. Jacques. 7. Vascular Pathology of Hyperhomocysteinemia; K.S. McCully. 8. Vascular Complications of Homocystinuria: Incidence, Clinical Pattern and Treatment; P. Rubba, et al. 9. Homocysteine as a Risk Factor for Peripheral Vascular Disease; A.M. Abou-Zamzam, Jr., et al. 10. Homocysteine as a Risk Factor for Cerebrovascular Disease and Stroke; I.J. Perry. 11. Homocysteine as a Risk Factor for Coronary Artery Disease; P.B. Duell, M.R. Malinow. 12. Homocysteine and Family History of Coronary Artery Disease; J. Genest, Jr. 13. Homocysteine as a Risk Factor for Cardiovascular Disease in Women; P. Verhoef. 14. Homocysteine and Venous Thrombosis; M. den Heijer. 15. Homocysteine and Renal Disease; K. Robinson, V.W. Dennis. 16. Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR): Interrelationships with Folic Acid, Homocysteine and Vascular Disease; R. Rozen. 17. Molecular Biology of Methionine Synthase: Interrelationships with Homocysteine and Vascular Disease; R. Banerjee. 18. Molecular Biology of Cystathionine -Synthase: Interrelationships with Homocysteine, Pyridoxine, and Vascular Disease; W.D. Kruger, B. Fowler. 19. Homocysteine and Cholesterol: Basic and Clinical Interactions; H.J. Blom. 20. Homocysteine and Coagulation Factors: Basic Interactions and Clinical Studies; R. Green. 21. Homocysteine and Endothelial Dysfunction; R.T. Eberhardt, J. Loscalzo. 22. The Treatment of High Homocysteine Concentrations in Homocystinuria: Biochemical Control in Patients and their Vascular Outcome; G.H.J. Boers, et al. 23. An Overview of the Homocysteine Lowering Clinical Trials; R. Clarke. 24. Summary and Future Directions for Epidemiological, Preventive and Basic Research; S.P. Fortmann, et al. Index.