Histone Deacetylases

Histone Deacetylases : Transcriptional Regulation and Other Cellular Functions

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Description

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
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Product details

  • Hardback | 352 pages
  • 160 x 230 x 32mm | 780.19g
  • Totowa, NJ, United States
  • English
  • 2006 ed.
  • 1 Illustrations, color; 62 Illustrations, black and white; 352 p. 63 illus., 1 illus. in color.
  • 1588294994
  • 9781588294999

Back cover copy

The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of leading investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small-molecule inhibitors-and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice.
Authoritative and state-of-the-art, Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions constitutes a first landmark of what has been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come.
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Table of contents

I. Class I Histone Deacetylases

Histone Deacetylase 1
Dominique Meunier and Christian Seiser

Biochemistry of Multiprotein HDAC Complexes
Alejandro Vaquero, Michael Scher, and Danny Reinberg

The Biology of HDAC3
Edward Seto

The Biology of HDAC8, a Unique Class I Histone Deacetylase
David Waltregny and Vincent Castronovo

II. Class II Histone Deacetylases

Regulation of Muscle Gene Expression by Histone Deacetylases
Timothy A. McKinsey and Eric N. Olson

The Class IIa Histone Deacetylases: Functions and Regulation
Herbert G. Kasler and Eric Verdin

Histone Deacetylases in the Response to Misfolded Proteins
J. Andrew McKee and Tso-Pang Yao

III. Class III Histone Deacetylases

Comparison of Sirtuin Sequences Between Archaea and Vertebrates
Roy A. Frye

Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases
Kehao Zhao and Ronen Marmorstein

The Enzymology of SIR2 Proteins
Margie T. Borra and John M. Denu

The Class III Protein Deacetylases: Homologs of Yeast Sir2p
Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, and Eric Verdin

IV. Histone Deacetylase Inhibitors

HDAC Inhibitors: Discovery, Development, and Clinical Impacts
Akihiro Ito, Norikazu Nishino, and Minoru Yoshida

Cell Cycle Targets of Histone Deacetylase Inhibitors
Brian Gabrielli

HDAC Inhibitors: An Emerging Anticancer Therapeutic Strategy
Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadja

Index
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