List of Principal Contributors. Preface. Section I: Cholestatic Liver Diseases: Physiology, Pathophysiology and Genetics. 1. Adaptive Responses in Bile Salt Transport Proteins in Cholangiocytes and Kidney in a Rat Model of Obstructive Cholestasis; J. Lee, et al. 2. Drug and Steroid Clearance by the Hepatic Organic Anion Transporting Protein Family; G.A. Kullak-Ublick, et al. 3. Down-regulation and Inhibition of 11beta-Hydroxysteroid Dehydrogenase: Another Explanation for Sodium Retention and Ascites Formation in Bile Duct-Ligated Rats; J. Reichen, et al. 4. The Role of Survival Signals in Bile Acid Modulation of Apoptosis; C. Rust, et al. 5. Genetic Transport Defects as Causes of Cholestasis; P.L.M. Jansen, M. Muller. Section II: Cholestatic Liver Diseases: Pathogenesis and Treatment. 6. Primary Biliary Cirrhosis: A Model Cholestatic Disease of Adults; M.E. Gershwin, et al. 7. Non-alcoholic Steatohepatitis (NASH): Potential Causes and Pathogenic Mechanisms; D. Pessayre, et al. 8. Current Therapeutic Approaches to Autoimmune Cholestatic Liver Disease; R. Poupon, R.E. Poupon. 9. Mechanisms of Action of Ursodeoxycholic Acid in Cholestasis; U. Beuers. 10. Endoscopic Treatment of Patients with Primary Sclerosing Cholangitis; A. Stiehl. Section III: Gallstone Disease. 11. Functional and Genetic Studies of Abcc2 in Inbred Mice: Evidence for a Primary Role of the Canalicular Conjugate Organic Anion Transporter in Lith2-transmitted Cholesterol Gallstone Susceptibility; G. Bouchard, et al. 12. Regulation of Biliary Lipid Secretion; A.K. Groen, R.P.J. Oude-Elferink. 13. Pathogenesis and Clinical Relevance of Biliary Sludge; S.P. Lee, C.W. Ko. 14. Treatment of Gallstone Disease Non-Surgical; M. Sackmann. 15. Surgical Treatment of Gallstone Disease; G. Meyer, et al. Section IV: Liver Cirrhosis: Pathogenesis and Treatment of Portal Hypertension. 16. Altered Function of Splanchnic Vasculature; D. Lebrec, R. Moreau. 17. Liver Cirrhosis: Pathogenesis and Treatment of Portal Hypertension Role of Hepatic Stellate Cells; M. Pinzani. 18. Pharmacotherapy of portal hypertension; J. Bosch. 19. The Transjugular Intrahepatic Portosystemic Shunt for Treatment of Variceal Bleeding; M. Roessle. Section V: Liver Cirrhosis: Pathogenesis and Treatment of Ascites and Encephalopathy. 20. Pathogenesis of Ascites and Hepatorenal Syndrome: Altered Haemodynamics and Neurohumoral Systems; M. Bernardi, P. Caraceni. 21. Therapy of Ascites and Hepatorenal Syndrome: Novel Approaches; V. Gulberg, A.L. Gerbes. 22. Spontaneous Bacterial Peritonitis, Treatment and Prophylaxis; P. Gines, R. Ortega. 23. Hepatic Encephalopathy; D. Haussinger, et al. Section VI: Viral Hepatitis: New Perspective on Pathogenesis and Molecular Virology.24. Pathogenesis of Hepatitis C Virus Infection; H.M. Diepolder, et al. 25. Viral Hepatitis and Hepatocellular Carcinoma; W.H. Caselmann. Section VII: Viral Hepatitis: Present and Future Perspectives in Therapy and Vaccine Development. 26. Viral Hepatitis: The Molecular Approach; H.E. Blum, et al. 27. Future Strategies in Hepatitis Therapy: The Immunological Approach; M.-C. Jung. Section VIII: Liver Transplantation: The Donor Organ. 28. Mechanisms of Ischemia Reperfusion Injury; H. Jaeschke. 29. Potential of Preconditioning; M. Bilzer, et al. 30. Sinusoidal Endothelial Cell Injury During Hepatic Preservation and Reperfusion; P.-A. Clavien. 31. Xeno-Transplantation the Future? E. Thein, C. Hammer. 32. Split Livers and Living Donors Where do we Stand Today? M. Hertl, et al. Section IX: Liver Transplantation: The Recipient. 33. Acute Liver Failure and Development of Liver Support Therapy; P. Neuhaus. 34. Problems of Viral Hepatitis in Liver Transplantation; M.P. Manns, et al. 35. Rejection and Immunosuppression: Novel Strategies; J. Neuberger. 36. Liver Transplantation: The Recipient Problems of Anaesthesia; M. Thiel, et al. 37. Liver Transplantation: The Munich Experience; H.G. Rau, et al. Index.