Hepatic Plasma Proteins : Mechanisms of Function and Regulation
The book contains information on the regualation of plasma proteins in health and disease. This comprehensive text describes plasma protein gene evolution, regulation by cytokines and transcription factors, expression in terms of genetic diseases, the structure - function relationships of the proteins, and their protective physiological and environmental roles. This text should be useful to geneticists, biochemists and molecular biologists concerned with plasma proteins in research and clinical settings. Current reviews of the following subjects are provided: regulatory mechanisms controlling plasma protein synthesis in the liver; genetic defects of plasma proteins in human diseases; evolution, chromosomal location, gene expression and regulation for major hepatic plasma protein; reactions of cytokines and transcription factors known to control blood levels of plasma proteins.
- Hardback | 285 pages
- 154.94 x 228.6 x 17.78mm | 612.35g
- 01 Jan 1993
- Elsevier Science Publishing Co Inc
- Academic Press Inc
- San Diego, United States
- index, illustrations, references
Table of contents
Part 1 Physiological and clinical implications of human plasma protein abnormalities: coagulation factors; plasma inhibitors; complement factors; apolipoproteins. Part 2 Acute phase reactants: the a1 - acid glycoprotein; c-readtive protein; serum amyloid protein (SAP); serum amyloid A (SAA); complement 3(C3); a2-HS-glycoprotein (AHSG); albumin. Part 3 The plasma proteinase inhibitors: variety of human plasma proteinase inhibitors; a1- antitrypsin. Part 4 Plasma protein vehicles: transferrin; ceruloplasmin; transtheyretin and the retinol binding protein; haptoglobin; hemopexin; vitamin D binding protein. Part 5 The biochemical regulators - cytokines and transcription factors: cytokines regulate changes in plasma protein sysnthesis; transcriptional factors in the nucleus regulate plasma protein gene expression by binding to specific DNA sequences; transcriptional factors interact with DNA sequences of plasma protein genes; references.