Hemostasis and Thrombosis
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Hemostasis and Thrombosis : Methods and Protocols

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Description

This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing.show more

Product details

  • Hardback | 565 pages
  • 178 x 254 x 31.75mm | 1,280g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 1st ed. 2017
  • 56 Tables, color; 49 Illustrations, color; 44 Illustrations, black and white; XV, 565 p. 93 illus., 49 illus. in color.
  • 1493971948
  • 9781493971947
  • 990,924

Back cover copy

This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing.show more

Table of contents

Part I: Introductory Chapters 1. Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders Roslyn A. Bonar, Giuseppe Lippi, and Emmanuel J. Favaloro 2. Preanalytical Issues in Hemostasis and Thrombosis Testing Giuseppe Lippi and Emmanuel J. Favaloro 3. The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing Massimo Franchini Part II: Routine Coagulation Assays 4. Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR) Emmanuel J. Favaloro 5. Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants Geoffrey Kershaw 6. Performance and Interpretation of Mixing Tests in Coagulation Geoffrey Kershaw 7. D-Dimer Testing: Laboratory Aspects and Current Issues Jecko Thachil, Giuseppe Lippi, and Emmanuel J. Favaloro 8. Determination of Fibrinogen and Thrombin Time (TT) Anetta Undas Part III: Thrombophilia-Related Chapters 9. An Overview of Thrombophilia and Associated Laboratory Testing Martina Montagnana, Giuseppe Lippi, and Elisa Danese 10. Laboratory Testing for Activated Protein C Resistance (APCR) Soma Mohammed and Emmanuel J. Favaloro 11. Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing Richard A. Marlar and Jana N. Gausman 12. Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing Richard A. Marlar and Jana N. Gausman 13. Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing Jana N. Gausman and Richard A. Marlar 14. Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT) Vittorio Pengo, Elisa Bison, Alessandra Banzato, Giacomo Zoppellaro, Seena Padayattil Jose, and Gentian Denas 15. Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT) Armando Tripodi and Veena Chantarangkul 16. Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris 17. Solid Phase Immunoassay for the Detection of Anti-ss2 Glycoprotein I Antibodies Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris 18. Measuring Direct Oral Anticoagulants Robert C. Gosselin and Jonathan Douxfils 19. Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing Kun Kan Edwin Lau, Soma Mohammed, Leonardo Pasalic, and Emmanuel J. Favaloro Part IV: Bleeding Disorders 20. One-Stage Factor VIII Assays Elizabeth Duncan and Susan Rodgers 21. Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A Susan Rodgers and Elizabeth Duncan 22. Assessment of Factor XIII Laszlo Muszbek, Eva Katona, and Adrienne Kerenyi 23. Detection and Measurement of Factor Inhibitors Geoffrey Kershaw 24. Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages and Disadvantages Anne-Mette Hvas and Erik Lerkevang Grove 25. Platelet Function Analyzed by Light Transmission Aggregometry Anne-Mette Hvas and Emmanuel J. Favaloro 26. Whole Blood Platelet Aggregometry George A. Fritsma and David L. McGlasson 27. Assessment of Platelet Function in Whole Blood by Flow Cytometry Leonardo Pasalic 28. Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood Leonardo Pasalic, Gabrielle J. Pennings, David Connor, Heather Campbell, Leonard Kritharides, and Vivien M. Chen 29. Diagnosis or Exclusion of Von Willebrand Disease Using Laboratory Testing Emmanuel J. Favaloro 30. Laboratory Testing for Von Willebrand Factor Antigen (VWF:Ag) Emmanuel J. Favaloro, Soma Mohammed, and Jurgen Patzke 31. Laboratory Testing for Von Willebrand Factor Collagen Binding (VWF:CB) Emmanuel J. Favaloro and Soma Mohammed 32. Laboratory Testing for Von Willebrand Factor Ristocetin Cofactor (VWF:RCo) Soma Mohammed and Emmanuel J. Favaloro 33. Laboratory Testing for Von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb) Jurgen Patzke and Emmanuel J. Favaloro 34. Laboratory Testing for Von Willebrand Factor Factor VIII Binding (for 2N VWD) Soma Mohammed and Emmanuel J. Favaloro 35. Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies Juan Pablo Frontroth and Emmanuel J. Favaloro 36. Laboratory Testing for Von Willebrand Factor Multimers Susan Oliver, Kun Kan Edwin Lau, Kent Chapman, and Emmanuel J. Favaloro Part V: Global Assays and Post-Analytical Issues 37. Thrombin Generation Assays (TGA) Gian Luca Salvagno and Erik Berntorp 38. The Overall Haemostatic Potential (OHP) Assay Jennifer Curnow 39. Thromboelastography (TEG) Maha Othman and Harmanpreet Kaur 40. Post-Analytical Issues in Hemostasis and Thrombosis Testing Emmanuel J. Favaloro and Giuseppe Lippishow more