Hemostasis and Thrombosis
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Hemostasis and Thrombosis : Methods and Protocols

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Description

This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing.
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Product details

  • Hardback | 565 pages
  • 178 x 254 x 31.75mm | 1,711g
  • Totowa, NJ, United States
  • English
  • 1st ed. 2017
  • 56 Tables, color; 49 Illustrations, color; 44 Illustrations, black and white; XV, 565 p. 93 illus., 49 illus. in color.
  • 1493971948
  • 9781493971947
  • 873,525

Back cover copy

This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing.
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Table of contents

Part I: Introductory Chapters



1. Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders

Roslyn A. Bonar, Giuseppe Lippi, and Emmanuel J. Favaloro



2. Preanalytical Issues in Hemostasis and Thrombosis Testing

Giuseppe Lippi and Emmanuel J. Favaloro



3. The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing

Massimo Franchini



Part II: Routine Coagulation Assays



4. Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR)

Emmanuel J. Favaloro



5. Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants

Geoffrey Kershaw



6. Performance and Interpretation of Mixing Tests in Coagulation

Geoffrey Kershaw



7. D-Dimer Testing: Laboratory Aspects and Current Issues

Jecko Thachil, Giuseppe Lippi, and Emmanuel J. Favaloro



8. Determination of Fibrinogen and Thrombin Time (TT)

Anetta Undas



Part III: Thrombophilia-Related Chapters



9. An Overview of Thrombophilia and Associated Laboratory Testing

Martina Montagnana, Giuseppe Lippi, and Elisa Danese



10. Laboratory Testing for Activated Protein C Resistance (APCR)

Soma Mohammed and Emmanuel J. Favaloro



11. Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing

Richard A. Marlar and Jana N. Gausman



12. Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing

Richard A. Marlar and Jana N. Gausman



13. Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing

Jana N. Gausman and Richard A. Marlar



14. Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT)

Vittorio Pengo, Elisa Bison, Alessandra Banzato, Giacomo Zoppellaro, Seena Padayattil Jose, and Gentian Denas



15. Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT)

Armando Tripodi and Veena Chantarangkul



16. Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies

Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris



17. Solid Phase Immunoassay for the Detection of Anti-ss2 Glycoprotein I Antibodies

Rohan Willis, Elizabeth Papalardo, and E. Nigel Harris



18. Measuring Direct Oral Anticoagulants

Robert C. Gosselin and Jonathan Douxfils



19. Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing

Kun Kan Edwin Lau, Soma Mohammed, Leonardo Pasalic, and Emmanuel J. Favaloro



Part IV: Bleeding Disorders



20. One-Stage Factor VIII Assays

Elizabeth Duncan and Susan Rodgers



21. Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A

Susan Rodgers and Elizabeth Duncan



22. Assessment of Factor XIII

Laszlo Muszbek, Eva Katona, and Adrienne Kerenyi



23. Detection and Measurement of Factor Inhibitors

Geoffrey Kershaw



24. Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages and Disadvantages

Anne-Mette Hvas and Erik Lerkevang Grove



25. Platelet Function Analyzed by Light Transmission Aggregometry

Anne-Mette Hvas and Emmanuel J. Favaloro



26. Whole Blood Platelet Aggregometry

George A. Fritsma and David L. McGlasson



27. Assessment of Platelet Function in Whole Blood by Flow Cytometry

Leonardo Pasalic



28. Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood

Leonardo Pasalic, Gabrielle J. Pennings, David Connor, Heather Campbell, Leonard Kritharides, and Vivien M. Chen



29. Diagnosis or Exclusion of Von Willebrand Disease Using Laboratory Testing

Emmanuel J. Favaloro



30. Laboratory Testing for Von Willebrand Factor Antigen (VWF:Ag)

Emmanuel J. Favaloro, Soma Mohammed, and Jurgen Patzke



31. Laboratory Testing for Von Willebrand Factor Collagen Binding (VWF:CB)

Emmanuel J. Favaloro and Soma Mohammed



32. Laboratory Testing for Von Willebrand Factor Ristocetin Cofactor (VWF:RCo)

Soma Mohammed and Emmanuel J. Favaloro



33. Laboratory Testing for Von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb)

Jurgen Patzke and Emmanuel J. Favaloro



34. Laboratory Testing for Von Willebrand Factor Factor VIII Binding (for 2N VWD)

Soma Mohammed and Emmanuel J. Favaloro



35. Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies

Juan Pablo Frontroth and Emmanuel J. Favaloro



36. Laboratory Testing for Von Willebrand Factor Multimers

Susan Oliver, Kun Kan Edwin Lau, Kent Chapman, and Emmanuel J. Favaloro



Part V: Global Assays and Post-Analytical Issues



37. Thrombin Generation Assays (TGA)

Gian Luca Salvagno and Erik Berntorp






38. The Overall Haemostatic Potential (OHP) Assay

Jennifer Curnow



39. Thromboelastography (TEG)

Maha Othman and Harmanpreet Kaur



40. Post-Analytical Issues in Hemostasis and Thrombosis Testing

Emmanuel J. Favaloro and Giuseppe Lippi
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