Hedgehog Signaling: Volume 88

Hedgehog Signaling: Volume 88

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hedgehog signaling.
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Product details

  • Hardback | 584 pages
  • 149.86 x 228.6 x 30.48mm | 907.18g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123946220
  • 9780123946225

Table of contents

Hedgehog Signaling
Siu Wah Choy, Shuk Han Cheng

Canonical and Non-Canonical Hedgehog/GLI Signaling in Hematological Malignancies
Fritz Aberger, Daniela Kern, Richard Greil and Tanja Nicole Hartmann

Non-Canonical Hedgehog Signaling
Donna Brennan, Xiaole Chen, Lan Cheng, My Mahoney, and Natalia A Riobo

Gli Protein Nuclear Localization Signal
Minoru Hatayama and Jun Aruga

Mammalian Homologues of Drosophila Fused Kinase
Alla Maloverjan and Marko Piirsoo

Identification, Functional Characterization and Pathobiological Significance of GLI1 Isoforms in Human Cancers
Richard L. Carpenter, Hui-Wen Lo

Gli-Similar (Glis) Proteins: Their Mechanisms of Action, Physiological Functions, and Roles in Disease
Kristin Lichti-Kaiser, Gary ZeRuth, Hong Soon Kang, Shivakumar Vasanth, and Anton M. Jetten

Sonic Hedgehog Regulates Wnt Activity During Neural Circuit Formation
Nicole H. Wilson and Esther T. Stoeckli

Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay
Alberto Gulino, Lucia Di Marcotullio, Gianluca Canettieri, Enrico Desmaele, Isabella Screpanti

Palmitoylation of Hedgehog Proteins
John A. Buglino and Marilyn D. Resh

Phosphorylation Regulation of Hedgehog Signaling
Jianhang Jia

Protein Kinase A Activity and Hedgehog Signaling Pathway
Tomoya Kotani

Phosphorylation of Gli by Camp-Dependent Protein Kinase
Yoshinari Asaoka

ZFP932 Suppresses Cellular Hedgehog Response and Patched1 Transcription
G. Jason Huang, Zhenhua He and Liang Ma

A New Era for an Ancient Drug; Arsenic Trioxide and Hedgehog Signaling
Elspeth M. Beauchamp and Aykut UEren

Aberrations and Therapeutics Involving the Developmental Pathway Hedgehog in Pancreatic Cancer
Fergal Crothur Kelleher

Sonic Hedgehog Signaling and Potential Therapeutic Indications
Nicholas C. Bambakidis, Kaine Onwuzulike

Sonic Hedgehog on Microparticles and Neovascularization
Raffaella Soleti and Maria Carmen Martinez

`Patch'-ing Up the Neurons: Revival or Enervation?
Sayantani Ghosh, Arunabha Chakrabarti and Debashis Mukhopadhyay

Activation of Hedgehog Pathway in Gastrointestinal Cancers
Ling Yang, Xiulan Su, Jingwu Xie

The Role Of Sonic Hedgehog as a Regulator of Gastric Function and Differentiation
Rui Feng, Chang Xiao and Yana Zavros

Sonic Hedgehog-Mediated Synergistic Effects Guiding Angiogenesis and Osteogenesis
Sabine Fuchs, Eva Dohle, Charles James Kirkpatrick

Hedgehog Inhibition as an Anti-Cancer Strategy

G. Praveen Raju, and Diane Pham
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About Gerald Litwack

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote "Human Biochemistry and Disease" a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, "One-Eighty".
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