Handbook of Physiology: Endocrine System Section 7

Handbook of Physiology: Endocrine System Section 7

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This unique volume provides fresh insights into the neuroendocrine systems that enable individuals to cope with their physical and social environments. Since the pioneering work of Claude Bernard and Walter Cannon on homeostasis and Hans Selye and John Mason on stress, there have been profound advances in biomedicine, and the regulation of gene expression has emerged as a major theme in connecting nature with nuture. With this has come an appreciation of the long time frame in which the environment produces both adaptive and maladaptive changes in an individual organism during the lifespan. Indeed, experiences early in life can have a life-long impact, and advances in behavioral and social sciences have interfaced with biology to reveal that the psychosocial environment shapes life-long patterns of neuroendocrine function and behavior, thus influencing physical and mental health. This book begins by discussing the two main stress mediators, the catecholamines and the hypothalamic-pituitary-adrenal axis. It then deals with the neurobiology of fear, stress and coping and with biological aspects of stress and coping during the life course. Next it considers diurnal rhythms, sleep and immune defense mechanisms. Finally it discusses stress and coping in the social environment in both animal models and humans. The book should provide an intellectual framework for further integration of social, psychological, and biological sciences around basic concepts in physiology.show more

Product details

  • Hardback | 574 pages
  • 222 x 286 x 34mm | 1,959.54g
  • Oxford University Press Australia
  • OUP Australia and New Zealand
  • Melbourne, Australia
  • English
  • numerous illustrations
  • 0195112520
  • 9780195112528

Table of contents

PART I: PRIMARY MEDIATORS OF THE COPING RESPONSE; 1. Synthesis, Storage and Secretion of Adrenal Medullary Hormones: Physiology and Pathophysiology; 2. Sympathetic Nervous System Physiology and Pathophysiology on Coping with the Environment; 3. Catecholamines in the Brain and Responses to Environmental Challenges; 4. Actions of ACTH of the Adrenal Cortex: Biochemistry and Cell Biology; 5. Proopiomelanocortin (POMC) Synthesis and Cell-specific processing; 6. Regulation and Actions of Corticotropin-releasing Hormone; 7. Corticotropin-releasing Factor in Brain: Executive Gating of Neuroendocrine and Functional Outflow; PART II: FEAR, STRESS, AND COPING; 8. Coping with Danger: The Neural Basis of Defensive Behavior and Fearful Feelings; 9. The Neurobiology of Interpreting and Responding to Stressful Events; Paradigmatic Role of the Hoppocampus; 10. Chronic Stress and Energy Balance: Role of the Hypothalamo-Pituitary Adrenal Axis; 11. Adrenocortical Responses to Stress adn their Modulation in Fre-living Vertebrates; PART III: STRESS AND COPING DURING THE LIFE COURSE; 12. Development of the Hypothalamus-Pituitary-Adrenal Axis and the Stress Response; 13. The Development of Individual differences in Behavioral and Endocrine Responses to Stress: The Roll of the Postnatal Environment; 14. Mechanisms of Glucocorticoid Actions in Stress and Brain Aging; PART IV: COPING AND DIURNAL RHYTHMS AND SLEEP; 15. Roles of Sleep-Wake and Dark-Light Cycles in the Control of Endocrine, Metabolic, Cariovascular, and Cognitive Function; 16. Sleep: Influence of Hormones and Cytokines; PART V: STRESS, COPING, AND IMMUNE DEFENSES; 17. Regional Neural Regulation of Immunity: Anatomy and Functions; 18. Role of Endogenous Glucocorticoids in Immune System Function: Regulation and Counterregulation; 19. Interactions Between the Hypothalamic-Pituitary-Adrenal Axis and Immune System During Viral Infection: Pathways for Environmental Effects on Disease Expression; 20. Regulation of Inflammatory Autoimmune Diseases; 21. Immunophysiology: The Interaction of Hormones, Lymphohemopoietic Cytokines and the Neuroimmune Axis; 22. Environmental Factors and Disease: Stress and Cancer; PART VI: STRESS, COPING, AND THE SOCIAL ENVIRONMENT; 23. The Physiological adn Pathophysiological Implications of Social Stress in Mammals; 24. Social Ordering and Healthshow more