Handbook of Pharmacology

Handbook of Pharmacology

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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1914 edition. Excerpt: ...would occur indirectly from the action of the drug on the circulation. The volume of the circulation through the kidney is often decreased by profound vasoconstriction in the acute stage, but in the general administration of digitalis the total efficiency of renal circulation is raised. Digitalis produces diuresis. This can be demonstrated on the normal animal, where diuresis is distinct though relatively slight. In pathological conditions, especially when involving the circulatory apparatus associated with dropsy and edema, this diuretic action is very greatly increased. The mechanism of diuresis by digitalis has been variously explained, by some authors as wholly vascular, by others as due to a direct influence of the drug on the renal epithelium. While one must admit the favorable vascular effects it seems that one cannot deny the direct renal stimulation. In relation to the clinical dropsical condition there is a disturbance of function of the vascular endothelium over the body which varies the regulative control as between the fluids inside the blood-vessels and the fluids in the lymph spaces and in the tissues. Digitalis produces some stimulation of this endothelial tissue, increasing its efficiency of action. It thereby favors the taking up and elimination of the excess of tissue fluids. Similar action also falls on the lining cells of the renal blood-vessels as well as on the renal epithelium. 9. The local irritating effect of digitalis.--Digitalis applied locally to mucous membranes or hypodermically injected into the cutaneous or muscular tissues, produces considerable local irritation. This irritation may lead to the usual cycle of inflammatory changes, even to the formation of local abscess. There is a sharp stimulation of the sensory...
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Product details

  • Paperback | 136 pages
  • 186 x 246 x 8mm | 258.55g
  • Miami Fl, United States
  • English
  • Illustrations, black and white
  • 1236636155
  • 9781236636157