Handbook of Opioid Bowel Syndrome

Handbook of Opioid Bowel Syndrome

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Description

How can medical professionals take advantage of the valuable effects of opiates while minimizing their most common side effect opioid bowel syndrome?

This groundbreaking book will help physicians in their day-to-day practice and help researchers and educators prepare the next generation of clinicians to make more efficient use of opioids. The Handbook of Opioid Bowel Syndrome presents complete, authoritative, current information on the mechanisms of action of opioids and the management of opioid bowel dysfunction-the number one reason physicians avoid prescribing opioids. Most chapters include charts, tables, and/or illustrations that make complex information about this vexing problem easy to access and understand. All are well-referenced for further study.

From the editor: "Opioid compounds, which are widely administered for a variety of medical indications, are associated with a number of side effects, especially opioid bowel dysfunction (OBD). Very often, OBD is so severe that physicians limit opioid use or dose, even when medically indicated. Although OBD is a significant clinical problem, it has received insufficient attention in the past within the medical community. This book presents complete, authoritative information on recent progress in understanding the mechanisms of action of opioids in relation to OBD and its management."

In 11 well-referenced chapters, the Handbook of Opioid Bowel Syndrome addresses:


gastrointestinal opioid physiology and pharmacology

the pathophysiology of opioid-induced bowel dysfunction

the epidemiology of OBD

OBD in palliative care

OBD in acute and chronic nonmalignant pain

post-operative OBD

post-surgical bowel dysfunction in the gynecological patient

new peripheral opioid antagonists currently under clinical development

Packed with information about opioids that was previously unavailable or difficult to find, the Handbook of Opioid Bowel Syndrome is an essential addition to the library of any clinician, researcher, or educator who needs current, essential knowledge about the best ways to utilize these quality-of-life enhancing medications.
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Product details

  • Electronic book text
  • CRC Press
  • London, United Kingdom
  • 1482289636
  • 9781482289633

Table of contents

About the Editor

Contributors

Preface

Introduction (Chun-Su Yuan and Marco Pappagallo)

SECTION I: BASIC CONCEPTS IN OPIOID BOWEL DYSFUNCTION

Chapter 1. Gastrointestinal Opioid Physiology and Pharmacology (Keri L. Fakata and Arthur G. Lipman)

Gastrointestinal Physiology

Opioid Effects on the Gastrointestinal System

Exogenous Opioid Effects on the Gastrointestinal System

Chapter 2. Pathophysiology of Opioid-Induced Bowel Dysfunction (Sangeeta R. Mehendale and Chun-Su Yuan)

Gastrointestinal Dysfunction Caused by Exogenous Opioids

Role of Endogenous Opioids in Normal and Impaired Gut Function

Chapter 3. Opioid-Induced Immunosuppression (Gang Wei, Jonathan Moss, and Chun-Su Yuan)

Studies of Opioid-Induced Immunosuppression

Is Opioid-Induced Immunosuppression Centrally Mediated?

Is Opioid-Induced Immunosuppression Peripherally Mediated?

Summary and Future Work

SECTION II: CLINICAL STATES

Chapter 4. The Epidemiology of Opioid Bowel Dysfunction (Ysmael Yap and Marco Pappagallo)

Introduction

Gastrointestinal Adverse Effects of Opioids

Prevalence in the General Population

Prevalence in the Opioid-Treated Population

Discussion

Chapter 5. Opioid Bowel Dysfunction in Palliative Care (Nigel P. Sykes)

Introduction

Constipation

Evaluation of Constipation

Management

Nausea and Vomiting

Conclusion

Chapter 6. Opioid Bowel Dysfunction in Acute and Chronic Nonmalignant Pain (Keri L. Fakata, Ashok K. Tuteja, and Arthur G. Lipman)

Introduction

Differentiating Pain Types

Opioid Bowel Dysfunction in Acute Pain

Opioid Bowel Dysfunction in Chronic Nonmalignant Pain

Is Opioid Bowel Dysfunction Properly Addressed in These Populations?

Current Treatment Options for Opioid Bowel Dysfunction

Conclusion

Chapter 7. Postoperative Bowel Dysfunction (Cormac Fahy and Tong J. Gan)

Introduction

Pathogenesis of Postoperative Ileus

Contribution of Perioperative and Postoperative Opioids

Role of General Anesthesia in Postoperative Bowel Dysfunction

Therapy of Postoperative Bowel Dysfunction

Conclusions

Chapter 8. Postsurgical Bowel Dysfunction in the Gynecologic Patient (Eric J. Bieber)

Introduction

Pathophysiology

Bowel Function After Hysterectomy

Effect of Early Feedings and NG Use on Bowel Function

Epidurals, General Anesthesia, and Patient-Controlled Analgesia

Opioid Antagonists

Conclusion

SECTION III: ADVANCES IN TREATING OPIOID BOWEL DYSFUNCTION

Chapter 9. Using Oral Naloxone in Management of Opioid Bowel Dysfunction (Nigel P. Sykes)

Evidence for a Peripheral Site of Opioid Constipating Action

Naloxone As an Opioid Antagonist

The Use of Naloxone for Treatment of Opioid-Induced Constipation

Discussion of Reported Clinical Studies

Use of Oral Naloxone for Idiopathic Constipation

Discussion of Reported Studies of Naloxone for Idiopathic Constipation

Chapter 10. Methylnaltrexone: Investigations in Treating Opioid Bowel Dysfunction (Thomas A. Boyd and Chun-Su Yuan)

Receptor-Binding Studies

Preclinical Studies

Absorption, Elimination, and Metabolism

Safety and Tolerance Studies in Humans

Efficacy Studies

Summary

Chapter 11. Management of Opioid-Induced Bowel Dysfunction and Postoperative Ileus: Potential Role of Alvimopan (Joseph F. Foss and William K. Schmidt)

Introduction

Preclinical Development

Clinical Development

Summary

Index

Reference Notes Included
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