Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas

Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas : Molecular Genetics: Liver and Pancreatic Carcinomas V3

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Description

Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer.

This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today.
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Product details

  • Hardback | 432 pages
  • 220 x 280 x 28mm | 1,800.78g
  • Academic Press Inc
  • San Diego, United States
  • English
  • Illustrations (some col.)
  • 0120884046
  • 9780120884049

Table of contents

Chapter 1: Quality Assurance in Immunohistochemistry

Chapter 2: Methodology of Microarray Data Analysis

Chapter 3: Microarray-Based Gene Expression Analysis of Defined Tumor Areas

Chapter 4: Tissue Microarray and Quantitative Fluorescence Image Analysis in Tumor Biomarker Analysis

Chapter 5: Identification of Differentially Expressed Genes Using Rapid Subtraction Hybridization: Detailed Methodology for Performing Rapid Subtraction Hybridization

Chapter 6: Noncontact Laser Microdissection and Pressure Catapulting: A Basic Tool in Genomics, Transcriptomics, and Proteomics

Chapter 7: DNA Methylation Analysis of Human Cancer

Chapter 8: Antiepidermal Growth Factor Receptor Antibody: Immunohistochemistry

Chapter 9: PTEN and Cancer

Chapter 10: The Role of p53 and p73 Genes in Tumor Formation

Chapter 11: Analysis of Centrosome Amplification in Cancer

Chapter 1: Liver Carcinoma

Chapter 2: Mechanisms of Human Hepatocarcinogenesis: An Overview

Chapter 3: Genes Involved in Hepatocellular Carcinoma

Chapter 4: Role of p53 and ZBP-89 in Hepatocellular Carcinoma

Chapter 5: Role of Immunohistochemical Expression of PTEN in Hepatocellular Carcinoma

Chapter 6: The Potential Role of Bcl-2 and Protein Expression in Hepatocellular Carcinomas: A Clinicopathologic Study

Chapter 7: The Detection and Clinical Aspect of Immunohistochemical Analysis of Bcl-xL Protein in Hepatocellular Carcinoma

Chapter 8: Growth Arrest DNA Damage-Inducible Gene 45 ss in Human Hepatocellular Carcinoma

Chapter 9: Immunohistochemical Detection of DNA Topoisomerase II in Hepatocellular Carcinoma

Chapter 10: Role of Immunohistochemical Expression of DNA Methyltransferases in Hepatocellular Carcinoma

Chapter 11: Role of Hepatitis B Surface Antigen in Hepatocarcinogenesis

Chapter 12: Immunohistochemical Detection of Host Gene Products Up-Regulated by Hepatitis B Virus X Antigen and Their Putative Roles in Hepatocellular Carcinoma

Chapter 13: Distinction between Well-Differentiated Hepatocellular Carcinoma and Benign Hepatocellular Nodular Lesions, Using Fine-Needle Aspiration Biopsy

Chapter 14: Immunohistochemical Detection of EBAG9/RCAS1 Expression in Hepatocellular Carcinoma

Chapter 15: Hepatocellular Carcinoma of Differential Viral Origin: Analysis by Oligonucleotide Microarray

Chapter 1: Pancreatic Carcinoma: An Introduction

Chapter 2: Detection of Genomic Imbalances in Endocrine Pancreatic Tumors Using Comparative Genomic Hybridization

Chapter 3: Molecular Detection of Micrometastases in Pancreatic Cancer

Chapter 4: K-ras Protooncogene in Human Pancreatic Cancer

Chapter 5: Altered Expression of p27 Protein in Pancreatic Carcinoma

Chapter 6: The Role of DUSP6/MKP-3 in Pancreatic Carcinoma

Chapter 7: Expression of Carbohydrate Antigens in Pancreatic Cancer

Chapter 8: Role of Mucins in Pancreatic Carcinoma

Chapter 9: Immunohistochemical Detection of Cyclooxygenase-2 in Pancreatic Ductal Adenocarcinomas and Neuroendocrine Tumors

Chapter 10: Immunohistochemical Detection of Activated Stat3 Protein in Pancreatic Cancer

Chapter 11: The Role of Transcription Factor E2F-1 in Pancreatic Ductal

Chapter 12: Role of Immunohistochemical Expression of Chromogranins in Pancreatic Endocrine Tumors

Chapter 13: Role of Immunohistochemical Expression of Maspin in Pancreatic Carcinoma

Chapter 14: Role of Mast Cells in Pancreatic Carcinoma

Chapter 15: Endocrine Cells in Invasive Ductal Adenocarcinoma of the Pancreas: An Immunohistochemical Study

Chapter 16: Fine-Needle Aspiration Biopsy of Pancreatic Adenocarcinoma

Chapter 17: Immunohistochemical Expression of Mitogen-Activated Protein Kinase Kinase 2 in Pancreatic Cancer

Index
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Review Text

"...this book contains a wealth of information of value to the oncologist and biomedical scientist."
--MICRON (2005)

"Professor Hayat's Handbook has the great potential of becoming the handbook of choice for clinician and basic scientists.
--Akhouri A. Sinha, Ph.D., Professor of Genetics, University of Minnesota and Research Scientist at the VA Medical Center "...this book contains a wealth of information of value to the oncologist and biomedical scientist."
--MICRON (2005)

"Professor Hayat's Handbook has the great potential of becoming the handbook of choice for clinician and basic scientists.
--Akhouri A. Sinha, Ph.D., Professor of Genetics, University of Minnesota and Research Scientist at the VA Medical Center
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Review quote

"...this book contains a wealth of information of value to the oncologist and biomedical scientist."
--MICRON (2005)

"Professor Hayat's Handbook has the great potential of becoming the handbook of choice for clinician and basic scientists."
--Akhouri A. Sinha, Ph.D., Professor of Genetics, University of Minnesota and Research Scientist at the VA Medical Center
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About M. A. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.
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